PMID- 17634280
OWN - NLM
STAT- MEDLINE
DCOM- 20071218
LR  - 20070917
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 82
IP  - 4
DP  - 2007 Oct
TI  - Bidirectional MHC molecule exchange between migratory and resident dendritic 
      cells.
PG  - 861-8
AB  - Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an 
      adjuvant in vivo. In this work, we analyzed the migration of transferred DC and 
      monitored the phenotype of new migrants in the draining lymph nodes. It is 
      surprising that we found that a majority of resident DCs expressed donor MHC 
      molecules and that a proportion of injected DCs acquired host MHC molecules. 
      These observations suggest that a bidirectional MHC molecule exchange occurs 
      between migratory and resident DCs, a mechanism that may amplify antigen 
      presentation in vivo.
FAU - de Heusch, Magali
AU  - de Heusch M
AD  - Institut de Biologie et Medecine Moleculaires, Universite Libre de Bruxelles, Rue 
      des Prof. Jeener et Brachet 12, 6041 Gosselies, Belgium.
FAU - Blocklet, Didier
AU  - Blocklet D
FAU - Egrise, Dominique
AU  - Egrise D
FAU - Hauquier, Bernard
AU  - Hauquier B
FAU - Vermeersch, Marjorie
AU  - Vermeersch M
FAU - Goldman, Serge
AU  - Goldman S
FAU - Moser, Muriel
AU  - Moser M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070718
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Animals
MH  - Cell Communication/*immunology
MH  - Cell Movement/*immunology
MH  - Dendritic Cells/cytology/*immunology/transplantation
MH  - Histocompatibility Antigens/*immunology
MH  - Lymph Nodes/cytology/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
EDAT- 2007/07/20 09:00
MHDA- 2007/12/19 09:00
CRDT- 2007/07/20 09:00
PHST- 2007/07/20 09:00 [pubmed]
PHST- 2007/12/19 09:00 [medline]
PHST- 2007/07/20 09:00 [entrez]
AID - jlb.0307167 [pii]
AID - 10.1189/jlb.0307167 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2007 Oct;82(4):861-8. doi: 10.1189/jlb.0307167. Epub 2007 Jul 18.