PMID- 17636480
OWN - NLM
STAT- MEDLINE
DCOM- 20080417
LR  - 20080205
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 37
IP  - 2
DP  - 2008 Feb
TI  - Interspike interval analysis in a patient with peripheral nerve hyperexcitability 
      and potassium channel antibodies.
PG  - 269-74
AB  - Neuromyotonia or Isaacs' syndrome is a rare peripheral nerve hyperexcitability 
      disorder caused by antibodies against potassium channels of myelinated axons. We 
      present the high-density surface electromyographic (EMG) recordings of a patient 
      with fasciculations and cramps due to neuromyotonia. To characterize the time 
      course of hyperexcitability, we analyzed the interspike intervals (ISIs) between 
      fasciculation potentials, doublet, and multiplet discharges. ISI duration 
      increased within each burst. The ISI histograms found can be explained by the 
      recovery cycle of the myelinated axon and its dependency on the slow potassium 
      conductance. We conclude that ISI analysis is a useful tool to understand the 
      membrane dynamics underlying abnormal motor unit activity.
FAU - Kleine, Bert U
AU  - Kleine BU
AD  - Department of Clinical Neurophysiology, Radboud University Nijmegen Medical 
      Centre, P.O. Box 9101, 6500HB Nijmegen, The Netherlands. b.kleine@neuro.umcn.nl
FAU - Stegeman, Dick F
AU  - Stegeman DF
FAU - Drost, Gea
AU  - Drost G
FAU - Zwarts, Machiel J
AU  - Zwarts MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Antibodies)
RN  - 0 (Potassium Channels)
SB  - IM
MH  - Action Potentials/*physiology/radiation effects
MH  - Aged
MH  - Antibodies/*blood
MH  - Electric Stimulation
MH  - Electromyography/methods
MH  - Female
MH  - Humans
MH  - *Isaacs Syndrome/blood/immunology/physiopathology
MH  - Potassium Channels/*immunology
EDAT- 2007/07/20 09:00
MHDA- 2008/04/18 09:00
CRDT- 2007/07/20 09:00
PHST- 2007/07/20 09:00 [pubmed]
PHST- 2008/04/18 09:00 [medline]
PHST- 2007/07/20 09:00 [entrez]
AID - 10.1002/mus.20849 [doi]
PST - ppublish
SO  - Muscle Nerve. 2008 Feb;37(2):269-74. doi: 10.1002/mus.20849.