PMID- 17637307
OWN - NLM
STAT- MEDLINE
DCOM- 20071129
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 46
IP  - 5
DP  - 2007 May
TI  - [The prognostic significance of derivative chromosome 9 deletions in chronic 
      myeloid leukemia].
PG  - 386-8
AB  - OBJECTIVE: To study the incidence and prognostic significance of derivative 
      chromosome 9 [der (9)] deletions in chronic myeloid leukemia (CMA). METHODS: 
      Dual-color dual-fusion BCR-ABL probe and fluorescence in situ hybridization 
      (FISH) were use to detect chromosome preparations from 48 randomly selected CML 
      patients in blast crisis (CML-BC). If only one fusion signal was detected in 
      interphase cells with FISH, metaphase cells were simultaneously observed to 
      determine if there were deletions on der (9). Chromosome preparations made at 
      diagnosis from those with der (9) deletions in CML-BC were also assayed to 
      determine if der (9) deletions occurred at the time of Philadelphia 
      translocation. Patients in chronic phase were treated with hydroxyurea. RESULTS: 
      Of the 48 CML-BC cases, 8 (16.7%) showed der (9) deletions and the deletions also 
      existed in chromosome preparations made at diagnosis. The group with der (9) 
      deletions had significantly shorter duration of chronic phase and overall 
      survival than the group without (P < 0.05). There was no difference in the 
      probability of the der (9) deletions between the cases transformed to acute 
      lymphoid leukemia and those to acute myeloid leukemia (P > 0.05). CONCLUSIONS: 
      FISH technique can effectively detect der (9) deletions. Der (9) deletions occur 
      at the time of Philadelphia translocation. CML patients with der (9) deletions 
      have more rapid process and poor prognosis. Hydroxyurea could not reverse the 
      poor prognosis of der (9) deletions in CML. Der (9) deletions might not lead to 
      transformation to specific type in CML.
FAU - Wu, Wei
AU  - Wu W
AD  - Department of Hematology, First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing 210029, China.
FAU - Li, Jian-Yong
AU  - Li JY
FAU - Shen, Yun-Feng
AU  - Shen YF
FAU - Cao, Xiang-Shan
AU  - Cao XS
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Xu, Wei
AU  - Xu W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Prognosis
EDAT- 2007/07/20 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/07/20 09:00
PHST- 2007/07/20 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/07/20 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2007 May;46(5):386-8.