PMID- 17639006
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20181201
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 90
IP  - 8
DP  - 2007 Aug
TI  - Genetic analysis of traits affecting the success of embryo transfer in dairy 
      cattle.
PG  - 3945-54
AB  - The primary aim of this study was to estimate variance components for traits 
      related to embryo transfer (ET) by applying generalized linear mixed models 
      (GLMM) for different distributions of traits (normal, binomial, and Poisson) in a 
      synergistic context. Synergistic models were originally developed for traits 
      affected by several genotypes, denoted as maternal, paternal, and direct effects. 
      In the case of ET, the number of flushed ova (FO) only depends on a donor's 
      maternal genetic effect, whereas paternal fertility must be considered for other 
      embryo survival traits, such as the number of transferable embryos (TE), the 
      number of degenerated embryos (DE), the number of unfertilized oocytes (UO), and 
      the percentage of transferable embryos (PTE). Data for these traits were obtained 
      from 4,196 flushes of 2,489 Holstein cows within 4 regions of northwest Germany 
      from January 1998 through October 2004. Estimates of maternal heritability were 
      0.231 for FO, 0.096 for TE, 0.021 for DE, 0.135 for UO, and 0.099 for PTE, 
      whereas the relative genetic impact of the paternal component was near zero. 
      Estimates of the genetic correlations between the maternal and the paternal 
      component were slightly negative, indicating a genetic antagonism. For the 
      analysis of pregnancy after ET, 8,239 transfers to 6,819 different 
      Holstein-Friesian recipients were considered by applying threshold methodology. 
      The direct heritability for pregnancy in the recipient after ET was 0.056. The 
      relative genetic impact of maternal and paternal components on pregnancy of 
      recipients describing a donor's and a sire's ability to produce viable embryos 
      was below 1%. The genetic correlations of the direct effect of the recipient with 
      the sire of embryos (paternal effect) and the donor cow (maternal effect) for 
      pregnancy after ET were -0.32 and -0.14, respectively. With the exception of FO 
      and PTE (-0.17), estimates of genetic correlations among traits for the maternal 
      site were distinctly positive, especially between FO and TE (0.74). Based on this 
      high genetic correlation and due to the higher heritability for FO, indirect 
      selection on FO will increase selection response in TE by about 22% compared with 
      direct selection on TE. The negative genetic correlation of -0.27 between TE and 
      lactation milk yield indicates the need for development of an index for bull dams 
      in multiple ovulation and embryo transfer (MOET) breeding schemes combining 
      production as well as traits related to ET.
FAU - Konig, S
AU  - Konig S
AD  - Department of Animal and Poultry Science, University of Guelph, N1G 2W1 Guelph, 
      Canada. skoenig2@gwdg.de
FAU - Bosselmann, F
AU  - Bosselmann F
FAU - von Borstel, U U
AU  - von Borstel UU
FAU - Simianer, H
AU  - Simianer H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Fats)
RN  - 0 (Milk Proteins)
SB  - IM
MH  - Animals
MH  - Cattle/embryology/*genetics/physiology
MH  - Dairying/methods
MH  - Embryo Transfer/standards/*veterinary
MH  - Embryonic Structures
MH  - Environment
MH  - Fats
MH  - Female
MH  - Genetic Variation
MH  - Lactation
MH  - Linear Models
MH  - Male
MH  - Milk/cytology/metabolism
MH  - Milk Proteins
MH  - *Models, Genetic
MH  - Oocytes
MH  - Ovulation/physiology
MH  - Phenotype
MH  - Pregnancy
MH  - Statistics as Topic
EDAT- 2007/07/20 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/07/20 09:00
PHST- 2007/07/20 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/07/20 09:00 [entrez]
AID - S0022-0302(07)71851-9 [pii]
AID - 10.3168/jds.2007-0089 [doi]
PST - ppublish
SO  - J Dairy Sci. 2007 Aug;90(8):3945-54. doi: 10.3168/jds.2007-0089.