PMID- 17640964
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20231213
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 171
IP  - 3
DP  - 2007 Sep
TI  - CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ 
      cells correlates with chronic obstructive pulmonary disease severity.
PG  - 767-76
AB  - Chronic obstructive pulmonary disease (COPD) is a progressive disease associated 
      with a cellular inflammatory response. CD8(+) T cells are implicated in COPD 
      pathogenesis, and their numbers significantly correlate with the degree of 
      airflow limitation. Dendritic cells (DCs) are important sentinel immune cells, 
      but little is known about their role in initiating and maintaining the CD8 T-cell 
      response in COPD. To investigate the mechanisms for CD8(+) T-cell recruitment to 
      the lung, we used resected human lung tissue to analyze chemokine receptor 
      expression by CD8(+) T cells and chemokine production by CD1a(+) DCs. Among 11 
      surveyed chemokine receptors, only CC chemokine receptor (CCR5), CXC chemokine 
      receptor (CXCR) 3, and CXCR6 correlated with COPD severity as defined by criteria 
      from the Global Initiative for Chronic Obstructive Lung Disease. The CD8(+) T 
      cells displayed a Tc1, CD45RA(+) effector memory phenotype. CD1a(+) DCs produced 
      the respective ligands for CCR5 and CXCR3, CCL3 and CXCL9, and levels correlated 
      with disease severity. CD1a(+) DCs also constitutively expressed the CXCR6 
      ligand, CXCL16. In conclusion, we have identified major chemokine elements that 
      potentially mediate CD8(+) T-cell infiltration during COPD progression and 
      demonstrated that CD1a(+) mucosal-associated DCs may sustain CD8(+) T-cell 
      recruitment/retention. Chemokine targeting may prove to be a viable treatment 
      approach.
FAU - Freeman, Christine M
AU  - Freeman CM
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, University of Michigan Health System, Ann Arbor, USA.
FAU - Curtis, Jeffrey L
AU  - Curtis JL
FAU - Chensue, Stephen W
AU  - Chensue SW
LA  - eng
GR  - T32 HL007749/HL/NHLBI NIH HHS/United States
GR  - A143460/PHS HHS/United States
GR  - CA46952/CA/NCI NIH HHS/United States
GR  - R01 HL082480/HL/NHLBI NIH HHS/United States
GR  - HL082480/HL/NHLBI NIH HHS/United States
GR  - R01 AI043460/AI/NIAID NIH HHS/United States
GR  - T32 HL07749/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070719
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CCL3 protein, human)
RN  - 0 (CD1a antigen)
RN  - 0 (CXCL16 protein, human)
RN  - 0 (CXCL9 protein, human)
RN  - 0 (CXCR3 protein, human)
RN  - 0 (CXCR6 protein, human)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CXCL16)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR3)
RN  - 0 (Receptors, CXCR6)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antigens, CD/genetics/metabolism
MH  - Antigens, CD1/genetics/metabolism
MH  - CD8-Positive T-Lymphocytes/cytology/*immunology
MH  - Cell Separation
MH  - Chemokine CCL3/genetics/metabolism
MH  - Chemokine CXCL16
MH  - Chemokine CXCL9/genetics/metabolism
MH  - Chemokines, CXC/genetics/metabolism
MH  - Dendritic Cells/cytology/metabolism
MH  - Humans
MH  - Immunoglobulins/genetics/metabolism
MH  - *Lung/cytology/immunology/pathology
MH  - Membrane Glycoproteins/genetics/metabolism
MH  - Middle Aged
MH  - Phenotype
MH  - *Pulmonary Disease, Chronic Obstructive/immunology/pathology/physiopathology
MH  - Receptors, CCR5/genetics/*metabolism
MH  - Receptors, CXCR3/genetics/metabolism
MH  - Receptors, CXCR6
MH  - Receptors, Chemokine/genetics/*metabolism
MH  - Receptors, Scavenger/genetics/metabolism
MH  - Receptors, Virus/genetics/*metabolism
MH  - CD83 Antigen
PMC - PMC1959492
EDAT- 2007/07/21 09:00
MHDA- 2007/12/07 09:00
PMCR- 2008/03/01
CRDT- 2007/07/21 09:00
PHST- 2007/07/21 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/07/21 09:00 [entrez]
PHST- 2008/03/01 00:00 [pmc-release]
AID - S0002-9440(10)62009-3 [pii]
AID - 10.2353/ajpath.2007.061177 [doi]
PST - ppublish
SO  - Am J Pathol. 2007 Sep;171(3):767-76. doi: 10.2353/ajpath.2007.061177. Epub 2007 
      Jul 19.