PMID- 17641165
OWN - NLM
STAT- MEDLINE
DCOM- 20070905
LR  - 20220408
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 317
IP  - 5840
DP  - 2007 Aug 17
TI  - A whole-genome association study of major determinants for host control of HIV-1.
PG  - 944-7
AB  - Understanding why some people establish and maintain effective control of HIV-1 
      and others do not is a priority in the effort to develop new treatments for 
      HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms 
      that explain nearly 15% of the variation among individuals in viral load during 
      the asymptomatic set-point period of infection. One of these is found within an 
      endogenous retroviral element and is associated with major histocompatibility 
      allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the 
      HLA-C gene. An additional analysis of the time to HIV disease progression 
      implicated two genes, one of which encodes an RNA polymerase I subunit. These 
      findings emphasize the importance of studying human genetic variation as a guide 
      to combating infectious agents.
FAU - Fellay, Jacques
AU  - Fellay J
AD  - Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome 
      Sciences and Policy, Duke University, Durham, NC 27710, USA.
FAU - Shianna, Kevin V
AU  - Shianna KV
FAU - Ge, Dongliang
AU  - Ge D
FAU - Colombo, Sara
AU  - Colombo S
FAU - Ledergerber, Bruno
AU  - Ledergerber B
FAU - Weale, Mike
AU  - Weale M
FAU - Zhang, Kunlin
AU  - Zhang K
FAU - Gumbs, Curtis
AU  - Gumbs C
FAU - Castagna, Antonella
AU  - Castagna A
FAU - Cossarizza, Andrea
AU  - Cossarizza A
FAU - Cozzi-Lepri, Alessandro
AU  - Cozzi-Lepri A
FAU - De Luca, Andrea
AU  - De Luca A
FAU - Easterbrook, Philippa
AU  - Easterbrook P
FAU - Francioli, Patrick
AU  - Francioli P
FAU - Mallal, Simon
AU  - Mallal S
FAU - Martinez-Picado, Javier
AU  - Martinez-Picado J
FAU - Miro, Jose M
AU  - Miro JM
FAU - Obel, Niels
AU  - Obel N
FAU - Smith, Jason P
AU  - Smith JP
FAU - Wyniger, Josiane
AU  - Wyniger J
FAU - Descombes, Patrick
AU  - Descombes P
FAU - Antonarakis, Stylianos E
AU  - Antonarakis SE
FAU - Letvin, Norman L
AU  - Letvin NL
FAU - McMichael, Andrew J
AU  - McMichael AJ
FAU - Haynes, Barton F
AU  - Haynes BF
FAU - Telenti, Amalio
AU  - Telenti A
FAU - Goldstein, David B
AU  - Goldstein DB
LA  - eng
GR  - G0200585/MRC_/Medical Research Council/United Kingdom
GR  - MC_U137884177/MRC_/Medical Research Council/United Kingdom
GR  - U19 AI067854/AI/NIAID NIH HHS/United States
GR  - U19 AI067854-03/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20070719
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HCP5 long noncoding RNA, human)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*57:01 antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (POLR1H protein, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Untranslated)
RN  - 0 (RNF39 protein, human)
SB  - IM
CIN - Science. 2007 Oct 19;318(5849):390-1; author reply 390-1. PMID: 17947564
MH  - Cohort Studies
MH  - DNA-Binding Proteins/genetics
MH  - Disease Progression
MH  - Female
MH  - Genes, MHC Class I
MH  - *Genome, Human
MH  - HIV Infections/*genetics/immunology/therapy/*virology
MH  - HIV-1/*physiology
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Immediate-Early Proteins/genetics
MH  - Major Histocompatibility Complex/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - RNA, Long Noncoding
MH  - RNA, Untranslated
MH  - Regression Analysis
MH  - Viral Load
PMC - PMC1991296
MID - NIHMS29209
EDAT- 2007/07/21 09:00
MHDA- 2007/09/06 09:00
PMCR- 2007/09/24
CRDT- 2007/07/21 09:00
PHST- 2007/07/21 09:00 [pubmed]
PHST- 2007/09/06 09:00 [medline]
PHST- 2007/07/21 09:00 [entrez]
PHST- 2007/09/24 00:00 [pmc-release]
AID - 1143767 [pii]
AID - 10.1126/science.1143767 [doi]
PST - ppublish
SO  - Science. 2007 Aug 17;317(5840):944-7. doi: 10.1126/science.1143767. Epub 2007 Jul 
      19.