PMID- 17641833
OWN - NLM
STAT- MEDLINE
DCOM- 20080702
LR  - 20181113
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 27
IP  - 3
DP  - 2007 Jun
TI  - Effect of salvia miltiorrhiza Bge on left ventricular hypertrophy and the 
      expression of tumor necrosis factor-alpha in spontaneously hypertensive rats.
PG  - 245-7
AB  - The effects of salvia miltiorrhiza Bge (SMB) on left ventricular hypertrophy 
      (LVH) and the expression of tumor necrosis factor-alpha (TNF-alpha) in the left 
      ventricle of spontaneously hypertensive rats and the action mechanism were 
      investigated. Normal Wistar-kyoto (WKY) rats were used as negative control, and 
      spontaneously hypertensive rats (SHR) were randomly assigned to receive placebo 
      or SMB. SMB (1 g/kg.d) was injected intraperitoneally for 12 weeks. Systolic 
      blood pressure (SBP) and left ventricular mass index (LVMI) were measured. HE, VG 
      and immunohistochemical staining combined with computed morphometry were employed 
      to evaluate the cardiomyocyte size, diameter, the collagen volume fraction (CVF), 
      perivascular circumferential area (PVCA), and tumor necrosis factor-alpha 
      (TNF-alpha) expression in the left ventricular tissue. The results showed, as 
      compared with WKY rats, the SBP, LVMI, cardiomyocyte size, diameter, CVF, PCVA, 
      and TNF-alpha expression were increased markedly in the 20-week-old spontaneously 
      hypertensive rats. SMB decreased LVMI (P<0.01), size of cardiomyocytes (P<0.01), 
      collagen volume fraction (P<0.01), perivascular circumferential area (P<0.01), 
      and TNF-alpha expression (P<0.01), but had no effect on SBP (P>0.05). It was 
      suggested that chronic administration of SMB could inhibit and reverse the 
      development of LVH in spontaneously hypertensive rats independent of BP. 
      TNF-alpha may be involved in the reversal mechanism of LVH by SMB.
FAU - Sun, Lianping
AU  - Sun L
AD  - Department of Emergency Medicine, Bejing Chuiyangliu Hospital, Beijing 100022, 
      China. sunlianping2002@yahoo.com.cn
FAU - Zheng, Zhi
AU  - Zheng Z
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Heart/drug effects/physiopathology
MH  - Hypertension/*complications
MH  - Hypertrophy, Left Ventricular/etiology/metabolism/*prevention & control
MH  - Immunohistochemistry
MH  - Male
MH  - Myocardium/metabolism/pathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Salvia miltiorrhiza/*chemistry
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
EDAT- 2007/07/21 09:00
MHDA- 2008/07/03 09:00
CRDT- 2007/07/21 09:00
PHST- 2006/12/18 00:00 [received]
PHST- 2007/07/21 09:00 [pubmed]
PHST- 2008/07/03 09:00 [medline]
PHST- 2007/07/21 09:00 [entrez]
AID - 10.1007/s11596-007-0307-7 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):245-7. doi: 
      10.1007/s11596-007-0307-7.