PMID- 17641922
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20220716
IS  - 0942-2056 (Print)
IS  - 0942-2056 (Linking)
VI  - 15
IP  - 7
DP  - 2007 Jul
TI  - Levels of biomarkers correlate with magnetic resonance imaging progression of 
      knee cartilage degeneration: a study on canine.
PG  - 869-78
AB  - To examine the association between levers of cartilage oligomeric matrix protein 
      (COMP), matrix metalloproteinases-1 (MMP-1), matrix metalloproteinases-3 (MMP-3), 
      tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in serum and synovial 
      fluid, and MR imaging of cartilage degeneration in knee joint, and to understand 
      the effects of movement training with different intensity on cartilage of knee 
      joint. 20 adult canines were randomly divided into three groups (8 in the light 
      training group; 8 in the intensive training group; 4 in the control group), and 
      canines of the two training groups were trained daily at different intensity. The 
      training lasted for 10 weeks in all. Magnetic resonance imaging (MRI) 
      examinations were performed regularly (2, 4, 6, 8, 10 week) to investigate the 
      changes of articular cartilage in the canine knee, while concentrations of COMP, 
      MMP-1, MMP-3, TIMP-1 in serum and synovial fluid were measured by ELISA assays. 
      We could find imaging changes of cartilage degeneration in both the training 
      groups by MRI examination during training period, compared with the control 
      group. However, there was no significant difference between these two training 
      groups. Elevations of levels of COMP, MMP-1, MMP-3, TIMP-1, MMP-3/TIMP-1 were 
      seen in serum and synovial fluid after training, and their levels had obvious 
      association with knee MRI grades of cartilage lesion. Furthermore, there were 
      statistically significant associations between biomarkers levels in serum and in 
      synovial fluid. Long-time and high-intensity movement training induces cartilage 
      degeneration in knee joint. Within the intensity extent applied in this study, 
      knee cartilage degeneration caused by light training or intensive training has no 
      difference in MR imaging, but has a comparatively obvious difference in 
      biomarkers level. To detect articular cartilage degeneration in early stage and 
      monitor pathological process, the associated application of several biomarkers 
      has a very good practical value, and can be used as a helpful supplement to MRI.
FAU - Qi, Chang
AU  - Qi C
AD  - Military Training Medicine Institute in the 150th Hospital of PLA, Luoyang, Henan 
      Province, China. changqi1127@yahoo.com.cn
FAU - Changlin, Huang
AU  - Changlin H
LA  - eng
PT  - Journal Article
DEP - 20070215
PL  - Germany
TA  - Knee Surg Sports Traumatol Arthrosc
JT  - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
JID - 9314730
RN  - 0 (Biomarkers)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Matrilin Proteins)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cartilage, Articular/*pathology
MH  - Dogs
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Extracellular Matrix Proteins/metabolism
MH  - Glycoproteins/metabolism
MH  - Knee Joint/metabolism/*pathology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Matrilin Proteins
MH  - Matrix Metalloproteinase 1/metabolism
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Models, Animal
MH  - Physical Conditioning, Animal/*methods
MH  - Random Allocation
MH  - Synovial Fluid/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/metabolism
EDAT- 2007/07/21 09:00
MHDA- 2007/10/19 09:00
CRDT- 2007/07/21 09:00
PHST- 2006/01/08 00:00 [received]
PHST- 2006/12/20 00:00 [accepted]
PHST- 2007/07/21 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/07/21 09:00 [entrez]
AID - 10.1007/s00167-006-0280-x [doi]
PST - ppublish
SO  - Knee Surg Sports Traumatol Arthrosc. 2007 Jul;15(7):869-78. doi: 
      10.1007/s00167-006-0280-x. Epub 2007 Feb 15.