PMID- 17645456
OWN - NLM
STAT- MEDLINE
DCOM- 20071107
LR  - 20211203
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 103
IP  - 1
DP  - 2007 Oct
TI  - Co-application of NMDA and dopamine-induced rapid translation of RSK2 in the 
      mature hippocampus.
PG  - 388-99
AB  - Ribosomal S6 kinase2 (RSK2) is known to take part in several signal transduction 
      cascades including Mitogen Activated Protein Kinase/Extracellular Regulated 
      Kinase (MAPK/ERK). Following our recent observation that ERK can serve as a 
      coincidence detector for fast and slow neurotransmission in the hippocampus, we 
      analyzed the status of RSK2 phosphorylation subsequent to application of NMDA, 
      dopamine, or both to preparations of mature hippocampal slices in Sprague-Dawley 
      rats. RSK2 was indeed phosphorylated; however, in addition, the amount of RSK2 
      protein (60%) was induced within 10 min following stimulation. Moreover, the 
      induced expression of RSK2 could be detected in both the cell body layer and the 
      dendrites of hippocampal CA1 cells. Pharmacological analysis showed that RSK2 
      induction was MAPK ERK Kinase (MEK)-ERK independent, but mammalian Target of 
      Rapamycin (mTOR) and translation dependent. We suggest that the fast kinetics of 
      RSK2 translation that follows physiological stimulations, together with recent 
      observations that its over-expression is vital for the attenuation of major 
      signal transduction cascades, indicate an expanded physiological function of RSK2 
      in neurons, and sheds new light on the role of RSK2 in the Coffin-Lowry syndrome.
FAU - Kaphzan, Hanoch
AU  - Kaphzan H
AD  - Department of Neurobiology and Ethology, Faculty of Science, Haifa University, 
      Haifa, Israel.
FAU - Doron, Guy
AU  - Doron G
FAU - Rosenblum, Kobi
AU  - Rosenblum K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070720
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 6384-92-5 (N-Methylaspartate)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 90-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (ribosomal protein S6 kinase, 90kDa, polypeptide 3)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Coffin-Lowry Syndrome/*metabolism
MH  - Dopamine/*pharmacology
MH  - Enzyme Induction/drug effects
MH  - Hippocampus/*drug effects/*metabolism
MH  - Male
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - N-Methylaspartate/*pharmacology
MH  - Organ Culture Techniques
MH  - Phosphorylation/drug effects
MH  - Protein Biosynthesis/drug effects
MH  - Protein Kinases/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ribosomal Protein S6 Kinases, 90-kDa/*biosynthesis/genetics
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases
EDAT- 2007/07/25 09:00
MHDA- 2007/11/08 09:00
CRDT- 2007/07/25 09:00
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2007/11/08 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
AID - JNC4774 [pii]
AID - 10.1111/j.1471-4159.2007.04774.x [doi]
PST - ppublish
SO  - J Neurochem. 2007 Oct;103(1):388-99. doi: 10.1111/j.1471-4159.2007.04774.x. Epub 
      2007 Jul 20.