PMID- 17645737
OWN - NLM
STAT- MEDLINE
DCOM- 20071102
LR  - 20070914
IS  - 0928-8244 (Print)
IS  - 0928-8244 (Linking)
VI  - 51
IP  - 1
DP  - 2007 Oct
TI  - Specific selection for virulent urinary tract infectious Escherichia coli strains 
      during catheter-associated biofilm formation.
PG  - 212-9
AB  - Biofilm-associated bacterial infections have a major impact on artificial 
      implants such as urinary catheters, often with devastating consequences. The 
      capacity of a microorganism to form a biofilm on a surface depends on the nature 
      of the surface and its conditioning. When a urinary catheter is exposed to urine, 
      various components adsorb onto the surface and form a conditioning film, which 
      becomes the real interface where microbial interaction takes place. It follows 
      that the material constituting the catheter determines the composition of the 
      conditioning film, which in turn influences which microorganisms can attach. 
      Urinary tract infectious (UTI) Escherichia coli range in pathogenicity and the 
      damage they cause--from benign asymptomatic bacteriuria (ABU) strains, which 
      inflict no or few problems to the host, to uropathogenic E. coli (UPEC) strains, 
      which are virulent and often cause severe symptoms and complications. We have 
      found that whereas ABU strains produce better biofilms on polystyrene and glass, 
      UPEC strains have a clear competitive advantage during biofilm growth on catheter 
      surfaces. Our results indicate that some silicone and silicone-latex catheters 
      actually select for and promote biofilm formation of the most virulent group of 
      UTI E. coli strains, hardly a desirable situation for the catheterized patient.
FAU - Ferrieres, Lionel
AU  - Ferrieres L
AD  - Microbial Adhesion Group, BioCentrum-DTU, Technical University of Denmark, 
      Lyngby, Denmark.
FAU - Hancock, Viktoria
AU  - Hancock V
FAU - Klemm, Per
AU  - Klemm P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070723
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (Polystyrenes)
RN  - 0 (Silicones)
SB  - IM
MH  - Biofilms/*growth & development
MH  - Catheters, Indwelling/*adverse effects
MH  - Escherichia coli/*physiology
MH  - Escherichia coli Infections/*microbiology
MH  - Female
MH  - Humans
MH  - Microscopy, Confocal
MH  - Polystyrenes
MH  - Silicones
MH  - Urinary Catheterization/*adverse effects
MH  - Urinary Tract Infections/*microbiology
MH  - Virulence
EDAT- 2007/07/25 09:00
MHDA- 2007/11/06 09:00
CRDT- 2007/07/25 09:00
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2007/11/06 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
AID - FIM296 [pii]
AID - 10.1111/j.1574-695X.2007.00296.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 2007 Oct;51(1):212-9. doi: 
      10.1111/j.1574-695X.2007.00296.x. Epub 2007 Jul 23.