PMID- 17645915
OWN - NLM
STAT- MEDLINE
DCOM- 20080407
LR  - 20131121
IS  - 0079-6123 (Print)
IS  - 0079-6123 (Linking)
VI  - 162
DP  - 2007
TI  - Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to 
      human.
PG  - 63-79
AB  - This chapter focuses on the effects of hyperthermia on drug and chemical 
      toxicity. In general, hyperthermia exacerbates the toxicity of many types of 
      drugs and environmental toxicants. Using rodents to model the potential responses 
      of humans to hyperthermic drugs is hampered by the unique differences in 
      thermoregulatory ability and body mass. Because of their relatively large surface 
      area:mass ratio, ambient temperature has a more profound influence on the 
      potential hyperthermic effect of a drug in rodents. The relative increase in heat 
      production (i.e., as a percentage of their basal metabolic rate) required to 
      raise core temperature by 1 degrees C will increase with a decrease in body mass. 
      The thermoregulatory response to methylenedioxymethamphetamine (MDMA) is used to 
      illustrate the differences in thermoregulatory responses of rats and humans to a 
      hyperthermic drug. Overall, the interaction between ambient temperature and 
      drug-induced changes in body temperature is critical in the evaluation of 
      hyperthermic-induced toxicity in rodent models.
FAU - Gordon, Christopher J
AU  - Gordon CJ
AD  - Neurotoxicology Division, National Health and Environmental Effects Research 
      Laboratory, B105-04, US Environmental Protection Agency, 109 S.T.W. Alexander 
      Drive, Research Triangle Park, NC 27711, USA. gordon.christopher@epa.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - *Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Body Temperature Regulation/*drug effects
MH  - Fever/*chemically induced/physiopathology
MH  - Humans
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
RF  - 47
EDAT- 2007/07/25 09:00
MHDA- 2008/04/09 09:00
CRDT- 2007/07/25 09:00
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
AID - S0079-6123(06)62005-0 [pii]
AID - 10.1016/S0079-6123(06)62005-0 [doi]
PST - ppublish
SO  - Prog Brain Res. 2007;162:63-79. doi: 10.1016/S0079-6123(06)62005-0.