PMID- 17646137
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20231103
IS  - 1570-0232 (Print)
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 855
IP  - 2
DP  - 2007 Aug 15
TI  - Validated liquid chromatographic-electrospray ionization mass spectrometric assay 
      for simultaneous determination of 3,4-methylenedioxymethamphetamine and its 
      metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 
      4-hydroxy-3-methoxymethamphetamine in squirrel monkey plasma.
PG  - 262-70
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug with neurotoxic 
      potential. Pharmacokinetic data of MDMA and its metabolites may shed light on the 
      mechanism of MDMA neurotoxicity. An LC-MS assay with electrospray ionization 
      (ESI) is presented for quantifying MDMA and its metabolites 
      3,4-methylenedioxyamphetamine (MDA), 3,4-dihydroxymethamphetamine (HHMA), and 
      4-hydroxy-3-methoxymethamphetamine (HMMA) in squirrel monkey plasma. The method 
      involved enzymatic conjugate cleavage and protein precipitation. Separation was 
      achieved within 14min. The method was validated according to international 
      guidelines with respect to selectivity, linearity, accuracy, precision, recovery, 
      and matrix effect. The present method should prove useful for acquiring 
      pharmacokinetic and toxicokinetic data in squirrel monkeys.
FAU - Mueller, Melanie
AU  - Mueller M
AD  - Department of Experimental and Clinical Toxicology, Institute of Experimental and 
      Clinical Pharmacology and Toxicology, Saarland University, D-66421 Homburg 
      (Saar), Germany.
FAU - Peters, Frank T
AU  - Peters FT
FAU - Ricaurte, George A
AU  - Ricaurte GA
FAU - Maurer, Hans H
AU  - Maurer HH
LA  - eng
GR  - F32 DA005707/DA/NIDA NIH HHS/United States
GR  - R01 DA005707/DA/NIDA NIH HHS/United States
GR  - DA017964/DA/NIDA NIH HHS/United States
GR  - K05 DA017964-04/DA/NIDA NIH HHS/United States
GR  - DA05707/DA/NIDA NIH HHS/United States
GR  - K05 DA017964/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Validation Study
DEP - 20070706
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Hallucinogens)
RN  - 117652-28-5 (4-hydroxy-3-methoxymethamphetamine)
RN  - 15398-87-5 (alpha-methylepinine)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
RN  - R7339QLN1C (Deoxyepinephrine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/blood/isolation & 
      purification
MH  - Animals
MH  - Calibration
MH  - Chromatography, Liquid/*methods
MH  - Deoxyepinephrine/analogs & derivatives/blood/isolation & purification
MH  - Hallucinogens/*blood/isolation & purification
MH  - Methamphetamine/analogs & derivatives/blood/isolation & purification
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*blood/isolation & purification
MH  - Saimiri
MH  - Spectrometry, Mass, Electrospray Ionization/*methods
PMC - PMC2682589
MID - NIHMS102211
EDAT- 2007/07/25 09:00
MHDA- 2007/12/07 09:00
PMCR- 2009/05/14
CRDT- 2007/07/25 09:00
PHST- 2007/04/15 00:00 [received]
PHST- 2007/06/18 00:00 [revised]
PHST- 2007/06/21 00:00 [accepted]
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
PHST- 2009/05/14 00:00 [pmc-release]
AID - S1570-0232(07)00457-6 [pii]
AID - 10.1016/j.jchromb.2007.06.034 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):262-70. doi: 
      10.1016/j.jchromb.2007.06.034. Epub 2007 Jul 6.