PMID- 17646722
OWN - NLM
STAT- MEDLINE
DCOM- 20080416
LR  - 20221207
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 30
IP  - 6
DP  - 2007 Jun
TI  - Age-related differences in metabolic response to continuous subcutaneous insulin 
      infusion in pre-pubertal and pubertal children with Type 1 diabetes mellitus.
PG  - 477-83
AB  - The aim of this study was to evaluate clinical and metabolic data in a cohort of 
      Type 1 diabetes (T1DM) children before and after 2 yr of continuous s.c. insulin 
      infusion (CSII). Forty seven T1DM patients were subdivided into two groups: Group 
      A (20 pre-pubertal children, mean age 7.43+/-3.19 yr); Group B (27 pubertal 
      adolescents, mean age 14.47+/-1.91 yr). No statistically significant differences 
      in body mass index (BMI) occurred in either groups after starting CSII or during 
      follow-up. The frequency of mild-hypoglycemias significantly declined during pump 
      therapy only in Group A (p<0.05). Both pre-pubertal and pubertal patients 
      required a significant reduction in their total insulin requirement after 12 and 
      24 months of CSII. The total percentage of daily insulin doses delivered as basal 
      rates was similar in both groups and was negatively associated (beta=-2.956, 
      p=0.05) with glycosylated hemoglobin (HbA1c) values. No significant correlation 
      was found between the percentage of the basal insulin rate and the number of 
      daily boluses. Differences in timing of the highest insulin requirement were 
      observed between the two groups. Group A had a higher insulin basal rate late in 
      the evening (20:00-24:00 h), while Group B had a higher insulin requirement early 
      in the morning (03:00-07:00 h). The HbA1c levels significantly improved in Group 
      A after 6-12 and 24 months of CSII. In Group B a reduction of HbA1c values was 
      observed only after 6 months of pump therapy (p=0.05). CSII is an effective 
      therapy for all ages but different metabolic requirements should also be taken 
      into account.
FAU - Rabbone, I
AU  - Rabbone I
AD  - Department of Pediatrics, University of Turin, 10126 Turin, Italy. 
      ivana.rabbone@unito.it
FAU - Bobbio, A
AU  - Bobbio A
FAU - Berger, K
AU  - Berger K
FAU - Trada, M
AU  - Trada M
FAU - Sacchetti, C
AU  - Sacchetti C
FAU - Cerutti, F
AU  - Cerutti F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Child
MH  - Child, Preschool
MH  - *Diabetes Mellitus, Type 1/drug therapy/metabolism
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - *Hypoglycemic Agents/administration & dosage/metabolism/therapeutic use
MH  - *Injections, Subcutaneous
MH  - *Insulin/administration & dosage/metabolism/therapeutic use
MH  - *Insulin Infusion Systems
MH  - Male
MH  - Puberty/*metabolism
EDAT- 2007/07/25 09:00
MHDA- 2008/04/17 09:00
CRDT- 2007/07/25 09:00
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2008/04/17 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
AID - 3780 [pii]
AID - 10.1007/BF03346331 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2007 Jun;30(6):477-83. doi: 10.1007/BF03346331.