PMID- 17646733 OWN - NLM STAT- MEDLINE DCOM- 20071129 LR - 20080306 IS - 1323-8930 (Print) IS - 1323-8930 (Linking) VI - 56 IP - 3 DP - 2007 Sep TI - Dendritic cells: nature and classification. PG - 183-91 AB - Dendritic cells (DCs) are antigen (Ag)-presenting cells (APCs) characterized by a unique capacity to stimulate naive T cells and initiate primary immune responses. Recent studies suggest that DCs also play critical roles in the induction of central and peripheral immunological tolerance, regulate the types of T cell immune responses, and function as sentinels in innate immunity against microbes. The diverse functions of DCs in immune regulation depend on the heterogeneity of DC subsets and their functional plasticity. Here we review recent progress in our understanding of the nature and classification of DCs. FAU - Sato, Katsuaki AU - Sato K AD - Laboratory for Dendritic Cell Immunobiology, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan. katsuaki@rcai.riken.jp FAU - Fujita, Shigeharu AU - Fujita S LA - eng PT - Journal Article PT - Review DEP - 20070801 PL - England TA - Allergol Int JT - Allergology international : official journal of the Japanese Society of Allergology JID - 9616296 SB - IM MH - Animals MH - Cell Lineage/*immunology MH - Dendritic Cells/*classification/*immunology MH - Humans MH - Mice RF - 59 EDAT- 2007/07/25 09:00 MHDA- 2007/12/06 09:00 CRDT- 2007/07/25 09:00 PHST- 2006/12/25 00:00 [received] PHST- 2007/07/25 09:00 [pubmed] PHST- 2007/12/06 09:00 [medline] PHST- 2007/07/25 09:00 [entrez] AID - S1323-8930(15)30864-9 [pii] AID - 10.2332/allergolint.R-06-139 [doi] PST - ppublish SO - Allergol Int. 2007 Sep;56(3):183-91. doi: 10.2332/allergolint.R-06-139. Epub 2007 Aug 1.