PMID- 17646980
OWN - NLM
STAT- MEDLINE
DCOM- 20071213
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 59
IP  - 10
DP  - 2007 Oct
TI  - Chain-terminating natural mutations affect the function of activating KIR 
      receptors 3DS1 and 2DS3.
PG  - 779-92
AB  - To determine the nucleotide polymorphism of activating killer-cell 
      immunoglobulin-like receptors (aKIR) 3DS1 and 2DS3, we developed a novel 
      direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals 
      and 72 KIR2DS3(+) individuals from the white population. The putative 
      ligand-binding extracellular immunoglobulin (Ig)-like domains of these aKIR 
      receptors are highly conserved, a scenario contrary to inhibitory KIRs that 
      recognize polymorphic human leukocyte antigen (HLA) class I molecules. Null 
      alleles 3DS1*049N and 2DS3*003N that do not express cell-surface receptors were 
      discovered, and they occur commonly in whites (3DS1*049N = 2%; 2DS3*003N = 0.8%). 
      Sequence-specific polymerase chain reaction (PCR) detecting these null alleles is 
      negative with DNA from nonwhite subjects, suggesting that these null alleles are 
      specific to whites and probably originated after the colonization of modern 
      humans in Europe.
FAU - Luo, Lihui
AU  - Luo L
AD  - UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, 
      David Geffen School of Medicine, University of California at Los Angeles, Los 
      Angeles, CA 90095-1652, USA.
FAU - Du, Zeying
AU  - Du Z
FAU - Sharma, Surendra K
AU  - Sharma SK
FAU - Cullen, Rebecca
AU  - Cullen R
FAU - Spellman, Stephen
AU  - Spellman S
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Rajalingam, Raja
AU  - Rajalingam R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070724
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (DNA Primers)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (KIR2DS3 protein, human)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR3DS1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - DNA Primers
MH  - Gene Expression Regulation/immunology
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Linkage Disequilibrium
MH  - Molecular Sequence Data
MH  - *Mutation
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics/immunology
MH  - Receptors, KIR3DS1/*genetics/immunology
MH  - Sequence Analysis/*methods
EDAT- 2007/07/25 09:00
MHDA- 2007/12/14 09:00
CRDT- 2007/07/25 09:00
PHST- 2007/03/15 00:00 [received]
PHST- 2007/06/01 00:00 [accepted]
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2007/12/14 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
AID - 10.1007/s00251-007-0239-1 [doi]
PST - ppublish
SO  - Immunogenetics. 2007 Oct;59(10):779-92. doi: 10.1007/s00251-007-0239-1. Epub 2007 
      Jul 24.