PMID- 17647101
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20220330
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 28
IP  - 5
DP  - 2008 Aug
TI  - Effects of the Chinese traditional prescription Xiaoyaosan decoction on chronic 
      immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 
      in rats.
PG  - 745-55
AB  - The Xiaoyaosan (XYS) decoction, a Chinese traditional prescription containing 
      eight commonly used herbs, has been used for treatment of mental disorders such 
      as depression for centuries in China. However, the mechanism underlying its 
      antidepressant activity is poorly understood. In rats with chronic immobilization 
      stress (CIS), we examined the effects of the XYS decoction on tail suspension 
      behavior and the levels of brain-derived neurotrophic factor (BDNF), tyroxine 
      hydroxylase (TrkB), and neurotrophin 3 (NT-3) in the frontal cortex and 
      hippocampus. Rats subjected to CIS exhibited decreases in weight-gain, food 
      intake, and ambulation in the open field test; they also showed an increase in 
      immobility in the tail suspension test. These were all attenuated by the XYS 
      decoction. Biochemically, the XYS decoction also reversed CIS-induced decreases 
      in BDNF and increases in TrkB and NT-3 in the frontal cortex and the hippocampal 
      CA(1) subregion. The behavioral effects of the XYS were correlated to the 
      biochemical actions. These results suggest that the XYS decoction produces an 
      antidepressant-like effect, which appears to be involved by BDNF in the brain.
FAU - Chen, Jia-Xu
AU  - Chen JX
AD  - School of Pre-clinical Medicine, Beijing University of Traditional Chinese 
      Medicine, No. 11 Beisanhuan Donglu, Chaoyang District, Beijing, P. R. China. 
      chenjx@bjucmp.edu.cn
FAU - Li, Wei
AU  - Li W
FAU - Zhao, Xin
AU  - Zhao X
FAU - Yang, Jian-Xing
AU  - Yang JX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070724
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (xiaoyaosan)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Appetite Regulation/drug effects/physiology
MH  - Body Weight/drug effects/physiology
MH  - Brain/*drug effects/metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/drug effects/metabolism
MH  - Chronic Disease/therapy
MH  - Down-Regulation/drug effects/physiology
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Nerve Growth Factors/*drug effects/metabolism
MH  - Neurotrophin 3/drug effects/metabolism
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/drug effects/metabolism
MH  - Restraint, Physical/psychology
MH  - Stress, Psychological/*drug therapy/metabolism/physiopathology
MH  - Treatment Outcome
MH  - Up-Regulation/drug effects/physiology
EDAT- 2007/07/25 09:00
MHDA- 2008/10/15 09:00
CRDT- 2007/07/25 09:00
PHST- 2006/12/22 00:00 [received]
PHST- 2007/06/15 00:00 [accepted]
PHST- 2007/07/25 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2007/07/25 09:00 [entrez]
AID - 10.1007/s10571-007-9169-6 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2008 Aug;28(5):745-55. doi: 10.1007/s10571-007-9169-6. Epub 
      2007 Jul 24.