PMID- 17649717
OWN - NLM
STAT- MEDLINE
DCOM- 20090930
LR  - 20070725
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 28
IP  - 1
DP  - 2007 Jan
TI  - [Detection of cytogenetic abnormalities involving chromosomes 5,7 and 8 in 
      myelodysplastic syndromes with fluorescence in situ hybridization and its 
      clinical significance].
PG  - 6-10
AB  - OBJECTIVE: To identify the abnormal karyotypes by fluorescence in situ 
      hybridization (FISH) and explore prognostic implications in patients with 
      myelodysplastic syndromes (MDS). METHODS: FISH was used to detect the frequently 
      occurring chromosome abnormalities (-5/5q, +8, -7/7q-) in 37 MDS cases. SPSS 11.5 
      software and correlation analysis were used to analyze the relativity among the 
      abnormal chromosomes, the prognosis and the disease conversion in 37 MDS 
      patients. RESULTS: Karyotype abnormalities were found in 21 (56.8%) of 37 cases, 
      among which 6 (16.2%) were complex karyotypes, 9 (24.3%) +8, 2(5.4%) -5/5q-, 
      2(5.4%) -7/7q-. In the median time of follow-up of 12 months, 12 cases 
      transformed into acute leukemia. Complex karyotypes were significantly associated 
      with the poor prognosis and leukemia transformation. + 8 and -7/7q- abnormalities 
      were correlated with the death. CONCLUSIONS: FISH was more sensitive than 
      conventional cytogenetics for detecting mini-clonal abnormality. There are some 
      differences in abnormal karyotypes between patients in China and the western 
      countries. Multi-probes used in cytogenetic detections may predict the patient' s 
      prognosis more accurately. The higher proportion of abnormal karyotypes the 
      poorer prognosis.
FAU - Cai, Yu
AU  - Cai Y
AD  - Department of Hematology, Shanghai Jiaotong University Affiliated First People's 
      Hospital, Shanghai 200080, China.
FAU - Qin, You-wen
AU  - Qin YW
FAU - Wang, Chun
AU  - Wang C
FAU - Yang, Juan
AU  - Yang J
FAU - Yan, Shi-ke
AU  - Yan SK
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
EDAT- 2007/07/26 09:00
MHDA- 2009/10/01 06:00
CRDT- 2007/07/26 09:00
PHST- 2007/07/26 09:00 [pubmed]
PHST- 2009/10/01 06:00 [medline]
PHST- 2007/07/26 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2007 Jan;28(1):6-10.