PMID- 17649718
OWN - NLM
STAT- MEDLINE
DCOM- 20090930
LR  - 20091119
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 28
IP  - 1
DP  - 2007 Jan
TI  - [Study of trisomy 22 and inversion 16 in acute myeloid leukemia].
PG  - 11-4
AB  - OBJECTIVE: To explore the value of trisomy 22 ( +22) in the diagnosis of inv(16) 
      acute myeloid leukemia (AML). METHODS: Interphase fluorescence in situ 
      hybridization (FISH) was performed in 18 AML patients with +22. The probe was 
      two-color break apart probe for CBFbeta with SpectrumRed on the centromeric side 
      and SpectrumGreen on the telomeric side. The FISH results were compared with that 
      of R-banding conventional cytogenetics (CC). Multiplex FISH (M-FISH) was used to 
      analyze the relationship of +22 and inv(16). RESULTS: CC revealed inv(16) in none 
      of the 18 AML, with +22, but FISH revealed inv (16) in 11 of them and del( 16) 
      (q22) in one. As CC results, 9 of the 11 cases were sole +22, one complicated 
      with trisomy 8, and one del(16) (q22). Four patients with +22 and inv(16) were 
      analyzed by M-FISH and revealed +22 only. CONCLUSION: +22 can be regarded as an 
      important marker for the diagnosis of inv(16) AML.
FAU - Zhou, Hui-fen
AU  - Zhou HF
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing 210029, China.
FAU - Li, Jian-yong
AU  - Li JY
FAU - Pan, Jin-lan
AU  - Pan JL
FAU - Qiu, Hai-rong
AU  - Qiu HR
FAU - Chen, Li-juan
AU  - Chen LJ
FAU - Hu, Jie-ying
AU  - Hu JY
FAU - Shen, Yun-feng
AU  - Shen YF
FAU - Xu, Wei
AU  - Xu W
FAU - Xue, Yong-quan
AU  - Xue YQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Chromosome Inversion
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
EDAT- 2007/07/26 09:00
MHDA- 2009/10/01 06:00
CRDT- 2007/07/26 09:00
PHST- 2007/07/26 09:00 [pubmed]
PHST- 2009/10/01 06:00 [medline]
PHST- 2007/07/26 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2007 Jan;28(1):11-4.