PMID- 17651374
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 18
IP  - 7
DP  - 2007 Nov
TI  - The predictive value of specific immunoglobulin E levels for the first diagnosis 
      of cow's milk allergy. A critical analysis of pediatric literature.
PG  - 575-82
AB  - Investigators have tried to identify a level of seric specific immunoglobulin E 
      (IgE) that had a sufficient predictive value to diagnose a food allergy without 
      having will resort to the food challenge. To search in literature, all the 
      studies that have estimated the possibility to identify a level of seric specific 
      cow milk IgE with a positive predictive value (PPV) of 95% for the first 
      diagnosis of cow's milk allergy (CMA) in pediatric age. We have identified six 
      studies, nearly all studies suffer from relevant methodological bias. Proposed 
      cut-off are all different. The studied pediatric populations were highly 
      selected. Also neglecting the methodological bias of the studies and the great 
      difference of value between the proposed cut-off, it always remains to consider 
      that the pre-test probability of having a CMA between the children enrolled in 
      the six studies included in this review is particularly high. The likelihood 
      ratio helps to transfer the results of a study on a diagnostic test just to our 
      population, and it is more realistic rather than to entrust itself to the PPV or 
      the negative predictive value, that are much influenced from the prevalence of 
      the disease in the studied population.
FAU - Miceli Sopo, Stefano
AU  - Miceli Sopo S
AD  - Department of Pediatrics, Catholic University of Rome, Rome, Italy. 
      stefano.micelisopo@poste.it
FAU - Radzik, Daniele
AU  - Radzik D
FAU - Calvani, Mauro
AU  - Calvani M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070725
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Biomedical Research/standards
MH  - Humans
MH  - Immunoglobulin E/*metabolism
MH  - Infant
MH  - Milk Hypersensitivity/*diagnosis/immunology
MH  - Predictive Value of Tests
RF  - 12
EDAT- 2007/07/27 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/07/27 09:00
PHST- 2007/07/27 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/07/27 09:00 [entrez]
AID - PAI595 [pii]
AID - 10.1111/j.1399-3038.2007.00595.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2007 Nov;18(7):575-82. doi: 
      10.1111/j.1399-3038.2007.00595.x. Epub 2007 Jul 25.