PMID- 17651427
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20220309
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 26
IP  - 3
DP  - 2007 Aug
TI  - A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in 
      rats.
PG  - 757-66
AB  - The medial prefrontal cortex (mPFC) is critical for reinstatement of cocaine 
      seeking and is the main source of brain-derived neurotrophic factor (BDNF) to 
      striatal regions of the brain relapse circuitry. To test the hypothesis that BDNF 
      in the mPFC regulates cocaine-seeking behavior, rats were trained to press a 
      lever for cocaine infusions (0.2 mg/inf, 2 h/day) paired with light+tone 
      conditioned stimulus (CS) presentations on 10 consecutive days. After the last 
      self-administration session, rats received a single infusion of BDNF (0.75 
      microg/0.5 microL/side) into the mPFC; this manipulation produced protracted 
      effects on cocaine-seeking behavior (non-reinforced lever pressing). BDNF 
      pretreatment administered after the last session attenuated cocaine seeking 22 h 
      later and, remarkably, it also blocked cocaine-induced suppression of 
      phospho-extracellular-regulated kinase and elevated BDNF immunoreactivity in the 
      nucleus accumbens. The same pretreatment also suppressed cocaine-seeking behavior 
      elicited by response-contingent CS presentations after 6 days of forced 
      abstinence or extinction training, as well as a cocaine challenge injection (10 
      mg/kg, i.p.) after extinction training. However, BDNF infused into the mPFC had 
      no effect on food-seeking behavior. Furthermore, BDNF infused on the sixth day of 
      abstinence failed to alter responding, suggesting that the regulatory influence 
      of BDNF is time limited. The suppressive effects of BDNF infused into the mPFC on 
      cocaine seeking indicate that BDNF regulates cortical pathways implicated in 
      relapse to drug seeking and that corticostriatal BDNF adaptations during early 
      abstinence diminish compulsive drug seeking.
FAU - Berglind, William J
AU  - Berglind WJ
AD  - Department of Neurosciences, Medical University of South Carolina, Charleston, SC 
      29425, USA.
FAU - See, Ronald E
AU  - See RE
FAU - Fuchs, Rita A
AU  - Fuchs RA
FAU - Ghee, Shannon M
AU  - Ghee SM
FAU - Whitfield, Timothy W Jr
AU  - Whitfield TW Jr
FAU - Miller, Scott W
AU  - Miller SW
FAU - McGinty, Jacqueline F
AU  - McGinty JF
LA  - eng
GR  - C06 RR015455/RR/NCRR NIH HHS/United States
GR  - P50 DA15369/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070725
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Cocaine/*adverse effects
MH  - Cocaine-Related Disorders/drug therapy/*metabolism/physiopathology
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Dopamine Uptake Inhibitors/adverse effects
MH  - Drug Administration Routes
MH  - Extracellular Signal-Regulated MAP Kinases/drug effects/metabolism
MH  - Male
MH  - Neural Pathways/drug effects/metabolism/physiopathology
MH  - Nucleus Accumbens/drug effects/metabolism/physiopathology
MH  - Prefrontal Cortex/*drug effects/*metabolism/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Secondary Prevention
MH  - Self Administration
MH  - Substance Withdrawal Syndrome/drug therapy/*metabolism/physiopathology
MH  - Time Factors
EDAT- 2007/07/27 09:00
MHDA- 2007/10/18 09:00
CRDT- 2007/07/27 09:00
PHST- 2007/07/27 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2007/07/27 09:00 [entrez]
AID - EJN5692 [pii]
AID - 10.1111/j.1460-9568.2007.05692.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 Aug;26(3):757-66. doi: 10.1111/j.1460-9568.2007.05692.x. 
      Epub 2007 Jul 25.