PMID- 17652427
OWN - NLM
STAT- MEDLINE
DCOM- 20071213
LR  - 20200930
IS  - 0363-6143 (Print)
IS  - 0363-6143 (Linking)
VI  - 293
IP  - 4
DP  - 2007 Oct
TI  - Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under 
      caloric restriction conditions.
PG  - C1302-8
AB  - Caloric restriction (CR) without malnutrition has been shown to increase maximal 
      life span and delay the rate of aging in a wide range of species. It has been 
      proposed that reduction in energy expenditure and oxidative damage may explain 
      the life-extending effect of CR. Sex-related differences also have been shown to 
      influence longevity and energy expenditure in many mammalian species. The aim of 
      the present study was to determine the sex-related differences in rat liver 
      mitochondrial machinery, bioenergetics, and oxidative balance in response to 
      short-term CR. Mitochondria were isolated from 6-mo-old male and female Wistar 
      rats fed ad libitum or subjected to 40% CR for 3 mo. Mitochondrial O(2) 
      consumption, activities of the oxidative phosphorylation system (complexes I, 
      III, IV, and V), antioxidative activities [MnSOD, glutathione peroxidase (GPx)], 
      mitochondrial DNA and protein content, mitochondrial H(2)O(2) production, and 
      markers of oxidative damage, as well as cytochrome C oxidase and mitochondrial 
      transcription factor A levels, were measured. Female rats showed a higher 
      oxidative capacity and GPx activity than males. This sexual dimorphism was not 
      modified by CR. Restricted rats showed slightly increased oxygen consumption, 
      complex III activity, and GPx antioxidant activity together with lower levels of 
      oxidative damage. In conclusion, the sexual dimorphism in liver mitochondrial 
      oxidative capacity was unaffected by CR, with females showing higher 
      mitochondrial functionality and ROS protection than males.
FAU - Valle, A
AU  - Valle A
AD  - Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i 
      Ciencies de la Salut, Universitat de les Illes Balears, E-07122, Palma de 
      Mallorca, Spain.
FAU - Guevara, R
AU  - Guevara R
FAU - Garcia-Palmer, F J
AU  - Garcia-Palmer FJ
FAU - Roca, P
AU  - Roca P
FAU - Oliver, J
AU  - Oliver J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070725
PL  - United States
TA  - Am J Physiol Cell Physiol
JT  - American journal of physiology. Cell physiology
JID - 100901225
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Tfam protein, rat)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (Transcription Factors)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.9.3.- (cytochrome C oxidase subunit II)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 7.1.1.2 (Electron Transport Complex I)
RN  - EC 7.1.1.8 (Electron Transport Complex III)
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - *Caloric Restriction
MH  - DNA, Mitochondrial/analysis
MH  - Electron Transport Complex I/metabolism
MH  - Electron Transport Complex III/metabolism
MH  - Electron Transport Complex IV/analysis/metabolism
MH  - Female
MH  - Glutathione Peroxidase/metabolism
MH  - Hydrogen Peroxide/metabolism
MH  - Liver/anatomy & histology/chemistry/metabolism
MH  - Male
MH  - Mitochondria, Liver/chemistry/*metabolism
MH  - Mitochondrial Proteins/analysis/metabolism
MH  - Organ Size/physiology
MH  - *Oxidative Phosphorylation
MH  - Oxygen Consumption/physiology
MH  - Protein Carbonylation/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Transcription Factors/analysis/metabolism
EDAT- 2007/07/27 09:00
MHDA- 2007/12/14 09:00
CRDT- 2007/07/27 09:00
PHST- 2007/07/27 09:00 [pubmed]
PHST- 2007/12/14 09:00 [medline]
PHST- 2007/07/27 09:00 [entrez]
AID - 00203.2007 [pii]
AID - 10.1152/ajpcell.00203.2007 [doi]
PST - ppublish
SO  - Am J Physiol Cell Physiol. 2007 Oct;293(4):C1302-8. doi: 
      10.1152/ajpcell.00203.2007. Epub 2007 Jul 25.