PMID- 17652838
OWN - NLM
STAT- MEDLINE
DCOM- 20070928
LR  - 20070726
IS  - 1735-1383 (Print)
IS  - 1735-1383 (Linking)
VI  - 4
IP  - 1
DP  - 2007 Mar
TI  - Dendritic cells in transplant tolerance.
PG  - 1-14
AB  - Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in 
      priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) 
      and recipient DCs presenting processed donor major histocompatibility complex 
      (MHC) as peptides (indirect pathway of allorecognition) participate actively in 
      graft rejection by stimulating recipient T cell responses following organ 
      transplantation. Recent studies have shown that DCs also play a central role in 
      inducing and maintaining tolerance to self antigens (Ags) through deletion, 
      anergy, and regulation mechanisms. It is easy to see how the remarkable 
      functional plasticity of DCs renders them attractive therapeutic targets for 
      immune modulation. Indeed, in the past few years, successful outcomes in rodent 
      models have built the case that DC-based therapy may provide a novel approach to 
      transplant tolerance. Ongoing research into our understanding of the mechanisms 
      whereby DCs promote tolerance in the steady-state, together with development of 
      biologically, pharmacologically and genetically manipulated ex vivo DCs to 
      mimic/enhance their natural tolerogenicity, should warrant the success of these 
      experimental DCs in establishing long-term allograft survival.
FAU - Nouri-Shirazi, Mahyar
AU  - Nouri-Shirazi M
AD  - Texas A&M University System Health Science Center, Baylor College of Dentistry, 
      Department of Biomedical Sciences, Immunology Laboratory, Dallas, TX 75246 USA. 
      MNshirazi@bcd.tamhsc.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Iran
TA  - Iran J Immunol
JT  - Iranian journal of immunology : IJI
JID - 101282932
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/*transplantation
MH  - Graft Rejection/immunology
MH  - Humans
MH  - Transplantation Tolerance/*immunology
RF  - 139
EDAT- 2007/07/27 09:00
MHDA- 2007/09/29 09:00
CRDT- 2007/07/27 09:00
PHST- 2007/07/27 09:00 [pubmed]
PHST- 2007/09/29 09:00 [medline]
PHST- 2007/07/27 09:00 [entrez]
AID - 01 [pii]
PST - ppublish
SO  - Iran J Immunol. 2007 Mar;4(1):1-14.