PMID- 17653442
OWN - NLM
STAT- MEDLINE
DCOM- 20080414
LR  - 20190606
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 40
IP  - 7
DP  - 2007 Jul
TI  - Effect of 4-aminoantipyrine on gastric compliance and liquid emptying in rats.
PG  - 903-9
AB  - Dipyrone (Dp) delays gastric emptying (GE) in rats. There is no information about 
      whether 4-aminoantipyrine (AA), one of its metabolites, has the same effect. The 
      objectives of the present study were to assess the effects of AA and Dp on GE 
      when administered intravenously (iv) and intracerebroventricularly (icv) (240 
      micromol/kg and 4 micromol/animal, respectively) and on gastric compliance when 
      administered iv (240 micromol/kg). GE was determined in male Wistar rats weighing 
      250-300 g (5-10 per group) after icv or iv injection of the drug by measuring 
      percent gastric retention (GR) of a saline meal labeled with phenol red 10 min 
      after administration by gavage. Gastric compliance was estimated in anesthetized 
      rats (10-11 per group), with the construction of volume-pressure curves during 
      intragastric infusion of a saline meal. Compliance was significantly greater in 
      animals receiving Dp (mean +/- SEM = 0.26 +/- 0.009 mL/mmHg) and AA (0.24 +/- 
      0.012 mL/mmHg) than in controls (0.19 +/- 0.009 mL/mmHg). AA and Dp administered 
      iv significantly increased GR (64.4 +/- 2.5 and 54.3 +/- 3.8%, respectively) 
      compared to control (34 +/- 2.2%), a phenomenon observed only with Dp after icv 
      administration. Subdiaphragmatic vagotomy reduced the effect of AA (GR = 31.4 +/- 
      1.5%) compared to sham-treated animals. Baclofen, a GABAB receptor agonist, 
      administered icv significantly reduced the effect of AA (GR = 28.1 +/- 1.3%). We 
      conclude that Dp and AA increased gastric compliance and AA delayed GE, with the 
      participation of the vagus nerve, through a pathway that does not involve a 
      direct action of the drug on the central nervous system.
FAU - Vinagre, A M
AU  - Vinagre AM
AD  - Nucleo de Medicina e Cirurgia Experimental, Faculdade de Ciencias Medicas, 
      Universidade Estadual de Campinas, Campinas, SP, Brasil.
FAU - Collares, E F
AU  - Collares EF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0M0B7474RA (Ampyrone)
RN  - 6429L0L52Y (Dipyrone)
SB  - IM
MH  - Ampyrone/administration & dosage/*pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology
MH  - Dipyrone/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Gastric Emptying/*drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
MH  - Vagus Nerve/drug effects
EDAT- 2007/07/27 09:00
MHDA- 2008/04/15 09:00
CRDT- 2007/07/27 09:00
PHST- 2006/09/29 00:00 [received]
PHST- 2007/05/09 00:00 [accepted]
PHST- 2007/07/27 09:00 [pubmed]
PHST- 2008/04/15 09:00 [medline]
PHST- 2007/07/27 09:00 [entrez]
AID - S0100-879X2007000700003 [pii]
AID - 10.1590/s0100-879x2006005000119 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2007 Jul;40(7):903-9. doi: 10.1590/s0100-879x2006005000119.