PMID- 17660653
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20070730
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 13
IP  - 2
DP  - 2002 Apr-Jun
TI  - Use of low molecular weight heparin for hemodialysis: a short-term study.
PG  - 146-50
AB  - Although unfractionated heparin (UFH) is the anticoagulant commonly used for 
      hemodialysis (HD), low molecular weight heparin (LMWH) has been found to be 
      equally efficacious. The aim of this study was to explore the safety and efficacy 
      of a single bolus dose of the LMWH, enoxaparin. Thirty-eight patients on 
      maintenance HD were randomly divided into two equal groups. The mean age and 
      body-weight of the two groups were comparable. While one group received 1 mg/kg 
      body-weight (the manufacturer's recommended dose) of enoxaparin for three 
      dialysis sessions of three-hours duration each, the other group received a fixed 
      dose of 40 mg for the same number of dialyses. For the next three dialysis 
      sessions, these doses were exchanged between the groups. In all, a total of 228 
      HD sessions were monitored for clotting of blood lines/dialyzers and bleeding 
      from vascular access and other sites. The rate of complications was compared with 
      the historical data while UFH was being used for the same patients. In general, 
      enoxaparin was associated with fewer episodes of bleeding and clotting. Our study 
      confirms that LMWH is of comparable efficacy to UFH and probably a lesser than 
      recommended dose is adequate for a three-hour HD session.
FAU - Al-Arrayed, Sameer
AU  - Al-Arrayed S
AD  - Consultant Nephrologist, Department of Nephrology, Salmaniya Medical Complex, 
      Bahrain.
FAU - Seshadri, Rajagopalan
AU  - Seshadri R
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
EDAT- 2007/07/31 09:00
MHDA- 2007/07/31 09:01
CRDT- 2007/07/31 09:00
PHST- 2007/07/31 09:00 [pubmed]
PHST- 2007/07/31 09:01 [medline]
PHST- 2007/07/31 09:00 [entrez]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2002 Apr-Jun;13(2):146-50.