PMID- 17661017
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20240511
IS  - 0033-3158 (Print)
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 195
IP  - 2
DP  - 2007 Dec
TI  - Acute and constitutive increases in central serotonin levels reduce social play 
      behaviour in peri-adolescent rats.
PG  - 175-82
AB  - RATIONALE: Serotonin is an important modulator of social behaviour. Individual 
      differences in serotonergic signalling are considered to be a marker of 
      personality that is stable throughout lifetime. While a large body of evidence 
      indicates that central serotonin levels are inversely related to aggression and 
      sexual behaviour in adult rats, the relationship between serotonin and social 
      behaviour during peri-adolescence has hardly been explored. OBJECTIVE: To study 
      the effect of acute and constitutive increases in serotonin neurotransmission on 
      social behaviour in peri-adolescent rats. MATERIALS AND METHODS: Social behaviour 
      in peri-adolesent rats (28-35 days old) was studied after genetic ablation of the 
      serotonin transporter, causing constitutively increased extra-neuronal serotonin 
      levels, and after acute treatment with the serotonin reuptake inhibitor 
      fluoxetine or the serotonin releasing agent 3,4-methylenedioxymethamphetamine 
      (MDMA). A distinction was made between social play behaviour that mainly occurs 
      during peri-adolescence, and non-playful social interactions that are abundant 
      during the entire lifespan of rats. RESULTS: In serotonin transporter knockout 
      rats, social play behaviour was markedly reduced, while non-playful aspects of 
      social interaction were unaffected. Acute treatment with fluoxetine or MDMA 
      dose-dependently inhibited social play behaviour. MDMA also suppressed 
      non-playful social interaction but at higher doses than those required to reduce 
      social play. Fluoxetine did not affect non-playful social interaction. 
      CONCLUSIONS: These data show that both acute and constitutive increases in 
      serotonergic neurotransmission reduce social play behaviour in peri-adolescent 
      rats. Together with our previous findings of reduced aggressive and sexual 
      behaviour in adult serotonin transporter knockout rats, these data support the 
      notion that serotonin modulates social behaviour in a trait-like manner.
FAU - Homberg, Judith R
AU  - Homberg JR
AD  - Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands. 
      j.homberg@niob.knaw.nl
FAU - Schiepers, Olga J G
AU  - Schiepers OJ
FAU - Schoffelmeer, Anton N M
AU  - Schoffelmeer AN
FAU - Cuppen, Edwin
AU  - Cuppen E
FAU - Vanderschuren, Louk J M J
AU  - Vanderschuren LJ
LA  - eng
PT  - Journal Article
DEP - 20070728
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Dose-Response Relationship, Drug
MH  - Fluoxetine/pharmacology
MH  - Male
MH  - Mutation
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/genetics
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - *Social Behavior
PMC - PMC2048539
EDAT- 2007/07/31 09:00
MHDA- 2008/02/26 09:00
PMCR- 2007/11/01
CRDT- 2007/07/31 09:00
PHST- 2007/03/21 00:00 [received]
PHST- 2007/07/09 00:00 [accepted]
PHST- 2007/07/31 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2007/07/31 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - 895 [pii]
AID - 10.1007/s00213-007-0895-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2007 Dec;195(2):175-82. doi: 
      10.1007/s00213-007-0895-8. Epub 2007 Jul 28.