PMID- 17661909
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 3
DP  - 2007 Sep
TI  - HLA-associated genetic resistance and susceptibility to type I diabetes in French 
      North Africans and French natives.
PG  - 214-8
AB  - The distribution of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1 haplotypes was 
      analyzed separately in two distinct French ethnic groups with type I diabetes 
      (T1D), i.e. French North African migrants (n= 64, mean age at diagnosis = 8.25 
      years) and ancient French natives (n= 60, mean age at diagnosis = 7.42 years). 
      HLA associations were determined by calculating odds ratios (ORs) between 
      patients and two ethnic-matched control populations. Results show highly similar 
      ORs for the conservative DRB1*0301-DQA1*0501-DQB1*0201 haplotype of 
      susceptibility (OR: 3.22 and 3.93 in migrants and natives, respectively) and the 
      DRB1*1501-DQA1*0102-DQB1*0602 haplotype of resistance (OR: 0.05 and 0.03, 
      respectively). In contrast, among the more variable DRB1*04-DQB1*0302 haplotypes 
      of susceptibility, the DRB1*0402 (OR: 3.10 and 32.84) and 0405 (OR: 5.90 and 
      16.25, respectively) were associated with T1D in migrants and natives, whereas an 
      increase of DRB1*0401, a rare allele in migrants, was significant in natives 
      only. Also, among the DRB1*11-DQA1*0505-DQB1*0301 haplotypes of resistance, the 
      OR observed for DRB1*1104-DQA1*0505-DQB1*0301, common in migrants, was lower (OR: 
      0.08) than for DRB1*1101-DQA1*0505-DQB1*0301 (OR: 0.32), common in natives. How 
      DRB1*11 subtypes might affect differently the risk conferred by 
      DQA1*0505-DQB1*0301 will be discussed.
FAU - Guerin, V
AU  - Guerin V
AD  - Laboratory of Immunology, Robert Debre Hospital, Assistance Publique des Hopitaux 
      de Paris, 48 boulevard Serurier, 75019 Paris, France. 
      valerie.guerin@rdb.ap-hop-paris.fr
FAU - Leniaud, L
AU  - Leniaud L
FAU - Pedron, B
AU  - Pedron B
FAU - Guilmin-Crepon, S
AU  - Guilmin-Crepon S
FAU - Tubiana-Rufi, N
AU  - Tubiana-Rufi N
FAU - Sterkers, G
AU  - Sterkers G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Africa, Northern/ethnology
MH  - *Black People
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - France/ethnology
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Infant
EDAT- 2007/07/31 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/07/31 09:00
PHST- 2007/07/31 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/07/31 09:00 [entrez]
AID - TAN878 [pii]
AID - 10.1111/j.1399-0039.2007.00878.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Sep;70(3):214-8. doi: 10.1111/j.1399-0039.2007.00878.x.