PMID- 17662528
OWN - NLM
STAT- MEDLINE
DCOM- 20071203
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 423
IP  - 1
DP  - 2007 Aug 9
TI  - Increased plasma brain-derived neurotrophic factor levels in chronic smokers 
      following unaided smoking cessation.
PG  - 53-7
AB  - Recent animal studies have suggested an association between nicotine and 
      alterations in brain-derived neurotrophic factor (BDNF) expression levels. 
      However, the role of BDNF in humans with nicotine dependence has not yet been 
      investigated. In this study, we explored the differences in the plasma BDNF 
      levels of chronic smokers and healthy nonsmokers, and we investigated the changes 
      in plasma BDNF levels in chronic smokers following unaided smoking cessation. 
      Forty voluntary participants (20 smokers and 20 nonsmokers) were enrolled in this 
      study. We measured the plasma BDNF levels at baseline (both groups) and at the 
      end of the two-month study period (smoker group only) using an enzyme-linked 
      immunosorbent assay. A total of 12 smokers (60.0%) completed the two-month study. 
      ANCOVA with age and body mass index as covariates showed that the baseline plasma 
      BDNF levels in smokers were significantly lower than those in nonsmokers 
      (F=4.626, p=0.038). The plasma BDNF levels in the smokers significantly increased 
      from baseline after the two-month smoking cessation period (Z=-3.059, p=0.002). 
      These findings suggest that BDNF may play a role in the pathophysiology of 
      smoking behavior.
FAU - Kim, Tae-Suk
AU  - Kim TS
AD  - Department of Psychiatry, Holy Family Hospital, The Catholic University of Korea, 
      College of Medicine, 2 Sosa-dong, Wonmi-gu, Pucheon City, Kyunggi-do 420-717, 
      Republic of Korea.
FAU - Kim, Dai-Jin
AU  - Kim DJ
FAU - Lee, Heejin
AU  - Lee H
FAU - Kim, Yong-Ku
AU  - Kim YK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20070704
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Carbon Monoxide/metabolism
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Male
MH  - Smoking/*blood/metabolism
MH  - *Smoking Cessation
EDAT- 2007/07/31 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/07/31 09:00
PHST- 2007/04/06 00:00 [received]
PHST- 2007/05/17 00:00 [revised]
PHST- 2007/05/23 00:00 [accepted]
PHST- 2007/07/31 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/07/31 09:00 [entrez]
AID - S0304-3940(07)00643-X [pii]
AID - 10.1016/j.neulet.2007.05.064 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Aug 9;423(1):53-7. doi: 10.1016/j.neulet.2007.05.064. Epub 
      2007 Jul 4.