PMID- 17663605
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20070731
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 121
IP  - 4
DP  - 2007 Aug
TI  - Time-specific extinction and recovery of the rabbit's (Oryctolagus cuniculus) 
      conditioned nictitating membrane response using mixed interstimulus intervals.
PG  - 808-13
AB  - Extinguishing a conditioned response (CR) has entailed separating the conditioned 
      stimulus (CS) from the unconditioned stimulus (US). This research reveals that 
      elimination of the rabbit nictitating membrane response occurred during 
      continuous CS-US pairings. Initial training contained a mixture of 2 CS-US 
      interstimulus intervals (ISIs), 150 ms and 500 ms. The CRs showed double peaks, 
      one for each ISI. When the 150-ms ISI was removed, its CR peak showed 2 hallmarks 
      of extinction: a decline across sessions and spontaneous recovery between 
      sessions. When a further stage of training was introduced with a distinctive CS 
      using the 150-ms ISI, occasional tests of the original, extinguished CS revealed 
      another hallmark of extinction, specifically, strong recovery of the 150-ms peak. 
      These results support both abstract and cerebellar models of conditioning that 
      encode the CS into a cascade of microstimuli, while challenging theories of 
      extinction that rely on changes in CS processing, US representations, and 
      contextual control.
CI  - ((c) 2007 APA, all rights reserved).
FAU - Dudeney, Joanne E
AU  - Dudeney JE
AD  - School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia.
FAU - Olsen, Kirk N
AU  - Olsen KN
FAU - Kehoe, E James
AU  - Kehoe EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Conditioning, Classical/*physiology
MH  - Extinction, Psychological/*physiology
MH  - Female
MH  - Male
MH  - Nictitating Membrane/*physiology
MH  - Rabbits
MH  - Time Factors
EDAT- 2007/08/01 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/08/01 09:00
PHST- 2007/08/01 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/08/01 09:00 [entrez]
AID - 2007-11112-017 [pii]
AID - 10.1037/0735-7044.121.4.808 [doi]
PST - ppublish
SO  - Behav Neurosci. 2007 Aug;121(4):808-13. doi: 10.1037/0735-7044.121.4.808.