PMID- 17663825
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20171116
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 46
IP  - 6
DP  - 2007 Jun
TI  - [A clinical study of 31 patients with malignant hematopoietic disease treated 
      with non-T cell-depleted HLA-haploidentical hematopoietic stem cell 
      transplantation].
PG  - 482-5
AB  - OBJECTIVE: To investigate the effects and prognosis of malignant hematological 
      disease after HLA haploidentical hematopoietic stem cell transplantation (H-HSCT) 
      without T-cell depletion. METHODS: The clinical data of 31 cases with malignant 
      hemopoietic disease treated with H-HSCT from July 2002 to July 2006 were 
      analyzed, including 11 cases of standard risk and 20 of high risk. RESULTS: 30 
      patients achieved engraftment of a median of 13 and 22 days for neutrophil and 
      platelet, with an accumulative incidence of II - IV grade acute graft-versus-host 
      disease (GVHD) 61.3%, and an accumulative incidence of chronic GVHD 41.9%. 13 
      patients survived with Karnofsky scale over 90.0% after a median follow-up of 24 
      months. 33 months of accumulative survival was 62.3% in the standard risk group 
      and 35.0% in the high risk group. The CD(3)(+) T cells count of the graft and the 
      disparity of HLA-A, B, DR loci were the major factors of impact on acute GVHD. 
      CONCLUSION: HLA H-HSCT is an effective therapeutic method for malignant 
      hematological disease, CD(3)(+) T cells count of the graft and the disparity of 
      HLA-A, B, DR loci are the major factors of impact on acute GVHD.
FAU - Yang, Ming-Zhen
AU  - Yang MZ
AD  - Department of Hematology, First Affiliated Hospital of Suzhou University, Jiangsu 
      Institute of Hematology, Suzhou 215006, China.
FAU - Yuan, Yan-Hui
AU  - Yuan YH
FAU - Wu, De-Pei
AU  - Wu DP
FAU - Chang, Wei-Rong
AU  - Chang WR
FAU - He, Jun
AU  - He J
FAU - Di, Wen-Ying
AU  - Di WY
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (CD3 Complex)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - CD3 Complex/analysis
MH  - Child
MH  - Female
MH  - Graft vs Host Disease/immunology/pathology
MH  - HLA Antigens/analysis
MH  - Haploidy
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Hematopoietic Stem Cells/*cytology/immunology/metabolism
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Leukemia/*surgery
MH  - Lymphocyte Depletion
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes/cytology/immunology/metabolism
MH  - Transplantation Conditioning
EDAT- 2007/08/01 09:00
MHDA- 2008/10/24 09:00
CRDT- 2007/08/01 09:00
PHST- 2007/08/01 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2007/08/01 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2007 Jun;46(6):482-5.