PMID- 17664559
OWN - NLM
STAT- MEDLINE
DCOM- 20071005
LR  - 20071203
IS  - 0031-9155 (Print)
IS  - 0031-9155 (Linking)
VI  - 52
IP  - 12
DP  - 2007 Jun 21
TI  - Investigation of optimal beam margins for stereotactic radiotherapy of 
      lung-cancer using Monte Carlo dose calculations.
PG  - 3549-61
AB  - This work investigated the selection of beam margins in lung-cancer stereotactic 
      body radiotherapy (SBRT) with 6 MV photon beams. Monte Carlo dose calculations 
      were used to systematically and quantitatively study the dosimetric effects of 
      beam margins for different lung densities (0.1, 0.15, 0.25, 0.35 and 0.5 g 
      cm(-3)), planning target volumes (PTVs) (14.4, 22.1 and 55.3 cm3) and numbers of 
      beam angles (three, six and seven) in lung-cancer SBRT in order to search for 
      optimal beam margins for various clinical situations. First, a large number of 
      treatment plans were generated in a commercial treatment planning system, and 
      then recalculated using Monte Carlo simulations. All the plans were normalized to 
      ensure that 95% of the PTV at least receives the prescription dose and compared 
      quantitatively. Based on these plans, the relationships between the beam margin 
      and quantities such as the lung toxicity (quantified by V20, the percentage 
      volume of the two lungs receiving at least 20 Gy) and the maximum target (PTV) 
      dose were established for different PTVs and lung densities. The impact of the 
      number of beam angles on the relationship between V20 and the beam margin was 
      assessed. Quantitative information about optimal beam margins for lung-cancer 
      SBRT was obtained for clinical applications.
FAU - Jin, L
AU  - Jin L
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA.
FAU - Wang, L
AU  - Wang L
FAU - Li, J
AU  - Li J
FAU - Luo, W
AU  - Luo W
FAU - Feigenberg, S J
AU  - Feigenberg SJ
FAU - Ma, C-M
AU  - Ma CM
LA  - eng
GR  - CA 78331/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070522
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - Humans
MH  - Lung Neoplasms/*radiotherapy
MH  - *Monte Carlo Method
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - *Tumor Burden
EDAT- 2007/08/01 09:00
MHDA- 2007/10/06 09:00
CRDT- 2007/08/01 09:00
PHST- 2007/08/01 09:00 [pubmed]
PHST- 2007/10/06 09:00 [medline]
PHST- 2007/08/01 09:00 [entrez]
AID - S0031-9155(07)38027-5 [pii]
AID - 10.1088/0031-9155/52/12/014 [doi]
PST - ppublish
SO  - Phys Med Biol. 2007 Jun 21;52(12):3549-61. doi: 10.1088/0031-9155/52/12/014. Epub 
      2007 May 22.