PMID- 17665305
OWN - NLM
STAT- MEDLINE
DCOM- 20080813
LR  - 20191210
IS  - 1573-3327 (Electronic)
IS  - 0009-398X (Linking)
VI  - 39
IP  - 2
DP  - 2008 Jun
TI  - Does diagnostic classification of early-onset psychosis change over follow-up?
PG  - 137-45
AB  - OBJECTIVE: To examine the diagnostic stability and the functional outcome of 
      patients with early-onset psychosis (EOP) over a 2-year follow-up period. 
      METHODS: A total of 24 patients (18 males (75%) and 6 females (25%), mean age +/- 
      SD: 15.7 +/- 1.6 years) with a first episode of EOP formed the sample. Psychotic 
      symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). 
      Social disability was measured with the Global Assessment of Functioning (GAF) 
      disability scale. Diagnosis was assessed using the Kiddie-Sads-Present and 
      Lifetime Version (K-SADS-PL), according to DSM-IV criteria. All diagnoses were 
      re-assessed after 1 year and 2 years. RESULTS: Schizophrenia had the highest 
      prospective consistency (100% predictive value), while diagnostic stability was 
      moderate for bipolar disorder (71.4%), and low for schizoaffective disorder 
      (50%), schizophreniform and brief psychosis (50%), and psychosis not otherwise 
      specified (NOS) (16.7%). The agreement between the baseline diagnoses and the 
      1-year follow-up diagnoses was 54.2%, whereas between the 1-year follow-up and 
      the 2-year follow-up, it rose to 95.7%. Regardless of diagnosis, baseline 
      negative symptoms were the only significant predictor of level of functioning at 
      the 2-year follow-up (p = 0.010). CONCLUSION: Our results highlight the primacy 
      of the first-year follow-up diagnosis in predicting diagnostic stability of EOP.
FAU - Fraguas, David
AU  - Fraguas D
AD  - Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Ibiza 
      43, CP 28009, Madrid, Spain. dfraguash@yahoo.es
FAU - de Castro, Maria J
AU  - de Castro MJ
FAU - Medina, Oscar
AU  - Medina O
FAU - Parellada, Mara
AU  - Parellada M
FAU - Moreno, Dolores
AU  - Moreno D
FAU - Graell, Montserrat
AU  - Graell M
FAU - Merchan-Naranjo, Jessica
AU  - Merchan-Naranjo J
FAU - Arango, Celso
AU  - Arango C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070731
PL  - United States
TA  - Child Psychiatry Hum Dev
JT  - Child psychiatry and human development
JID - 1275332
SB  - IM
MH  - Adolescent
MH  - Bipolar Disorder/diagnosis/therapy
MH  - Child
MH  - *Early Diagnosis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Likelihood Functions
MH  - Linear Models
MH  - Male
MH  - Predictive Value of Tests
MH  - Psychological Tests
MH  - Psychotic Disorders/*diagnosis
MH  - Reproducibility of Results
MH  - Schizophrenia/diagnosis/therapy
MH  - Spain
MH  - Time Factors
EDAT- 2007/08/01 09:00
MHDA- 2008/08/14 09:00
CRDT- 2007/08/01 09:00
PHST- 2007/02/01 00:00 [received]
PHST- 2007/07/16 00:00 [accepted]
PHST- 2007/08/01 09:00 [pubmed]
PHST- 2008/08/14 09:00 [medline]
PHST- 2007/08/01 09:00 [entrez]
AID - 10.1007/s10578-007-0076-3 [doi]
PST - ppublish
SO  - Child Psychiatry Hum Dev. 2008 Jun;39(2):137-45. doi: 10.1007/s10578-007-0076-3. 
      Epub 2007 Jul 31.