PMID- 17665548
OWN - NLM
STAT- MEDLINE
DCOM- 20070828
LR  - 20131121
IS  - 0016-254X (Print)
IS  - 0016-254X (Linking)
VI  - 98
IP  - 6
DP  - 2007 Jun
TI  - Case of paroxysmal atrial fibrillation improved after the administration of 
      proton pump inhibitor for associated reflux esophagitis.
PG  - 270-6
AB  - A 64-year-old man had demonstrated palpitations caused by paroxysmal atrial 
      fibrillation (AF) documented by ambulatory electrocardiographic monitoring. 
      Effectiveness of antiarrhythmic agent (disopyramide: 300 mg/day) was limited. 
      Based on the gastrointestinal endoscopic findings, proton pump inhibitor (PPI: 
      rabeprazole, 10 mg/day) was administered to eliminate heart burn due to reflux 
      esophagitis. Symptoms of paroxysmal AF and reflux esophagitis were confusing due 
      to the anatomical proximity of the diseased organs and concomitant occurrence in 
      the evening and when in a supine position. After the additional PPI therapy, not 
      only was reflux esophagitis improved subjectively and endoscopically but also 
      paroxysms of AF markedly reduced. Because esophagus is attached to left atrial 
      posterior wall and the role of inflammatory process on the development of AF is 
      highlighted, amelioration of reflux esophagitis by PPI may have been followed by 
      the remarkable reduction of paroxysms of AF.
FAU - Nakamura, Hirofumi
AU  - Nakamura H
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, 812-8582, Japan.
FAU - Nakaji, Gen
AU  - Nakaji G
FAU - Shimazu, Hideki
AU  - Shimazu H
FAU - Yasuda, Shioto
AU  - Yasuda S
FAU - Odashiro, Keita
AU  - Odashiro K
FAU - Maruyama, Toru
AU  - Maruyama T
FAU - Kaji, Yoshikazu
AU  - Kaji Y
FAU - Chishaki, Akiko
AU  - Chishaki A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Fukuoka Igaku Zasshi
JT  - Fukuoka igaku zasshi = Hukuoka acta medica
JID - 9423321
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*therapeutic use
MH  - Atrial Fibrillation/*drug therapy/*etiology
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Esophagitis, Peptic/*complications/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Proton Pump Inhibitors
MH  - Rabeprazole
MH  - Treatment Outcome
EDAT- 2007/08/02 09:00
MHDA- 2007/08/29 09:00
CRDT- 2007/08/02 09:00
PHST- 2007/08/02 09:00 [pubmed]
PHST- 2007/08/29 09:00 [medline]
PHST- 2007/08/02 09:00 [entrez]
PST - ppublish
SO  - Fukuoka Igaku Zasshi. 2007 Jun;98(6):270-6.