PMID- 17666060
OWN - NLM
STAT- MEDLINE
DCOM- 20071107
LR  - 20070919
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Linking)
VI  - 18
IP  - 10
DP  - 2007 Sep
TI  - Effect of pacing the right ventricular mid-septum tract in patients with 
      permanent atrial fibrillation and low ejection fraction.
PG  - 1032-6
AB  - INTRODUCTION: Permanent right ventricular (RV) pacing leads have been 
      traditionally implanted in the right ventricular apex (RVA). Nowadays, some 
      deleterious effects of RVA pacing have been recognized. The aim of this study was 
      to evaluate the effect of different sites of RV pacing in patients with permanent 
      atrial fibrillation (AF) and low ejection fraction (LEF) needing a pacemaker (PM) 
      implantation. METHODS: Two hundred seventy-three patients with permanent AF and 
      EF <30% underwent a one-chamber rate responsive (VVIR) PM implant procedure. 
      Patients were divided into two groups: Group A, including 113 patients with the 
      pacing lead tip placed in the RV mid-septum, and Group B of 120 patients with the 
      pacing lead tip placed at the apex of RV. All patients had clinical and Echo 
      control after 1, 3, 6, 12, and 18 months after PM implantation to assess New York 
      Heart Association (NYHA) class and EF. RESULTS: After 18 months, NYHA class 
      changed in Group A from 2.9 +/- 0.4 at implant to 1.7 +/- 0.3 at 18 months (P = 
      0.01), and in Group B from 3.0 +/- 0.5 at implant to 3.3 +/- 0.6 at 18 months (P 
      = n.s.). EF increased in Group A: 28 +/- 2% at implant, 33 +/- 1% at 18 months (P 
      = 0.0125), while no significant changes were observed in Group B: at implant 27 
      +/- 2%, 26 +/- 2% at 18 months (P = n.s.). CONCLUSION: The present study suggests 
      that more physiological pacing from the RV sept can improve EF and quality of 
      life (QoL) in patients with permanent AF and low EF needing a PM.
FAU - Muto, Carmine
AU  - Muto C
AD  - Electrophysiology Laboratory, Department of Cardiology, S.M. Loreto Mare 
      Hospital, Naples, Italy.
FAU - Ottaviano, Luca
AU  - Ottaviano L
FAU - Canciello, Michelangelo
AU  - Canciello M
FAU - Carreras, Giovanni
AU  - Carreras G
FAU - Calvanese, Raimondo
AU  - Calvanese R
FAU - Ascione, Luigi
AU  - Ascione L
FAU - Iengo, Raffaele
AU  - Iengo R
FAU - Accadia, Maria
AU  - Accadia M
FAU - Celentano, Eduardo
AU  - Celentano E
FAU - Tuccillo, Bernardino
AU  - Tuccillo B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20070730
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
CIN - J Cardiovasc Electrophysiol. 2007 Sep;18(10):1037-8. PMID: 17877466
MH  - Aged
MH  - Atrial Fibrillation/*physiopathology/therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Follow-Up Studies
MH  - Heart Septum/physiology
MH  - Humans
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Stroke Volume/*physiology
MH  - Ventricular Dysfunction, Left/*physiopathology/therapy
MH  - Ventricular Function, Right/*physiology
EDAT- 2007/08/02 09:00
MHDA- 2007/11/08 09:00
CRDT- 2007/08/02 09:00
PHST- 2007/08/02 09:00 [pubmed]
PHST- 2007/11/08 09:00 [medline]
PHST- 2007/08/02 09:00 [entrez]
AID - JCE914 [pii]
AID - 10.1111/j.1540-8167.2007.00914.x [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2007 Sep;18(10):1032-6. doi: 
      10.1111/j.1540-8167.2007.00914.x. Epub 2007 Jul 30.