PMID- 17666781
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20181113
IS  - 1234-1983 (Print)
IS  - 1234-1983 (Linking)
VI  - 48
IP  - 3
DP  - 2007
TI  - Lack of association of HLA-C alleles with late-onset psoriasis in the northern 
      Polish population.
PG  - 273-5
AB  - The HLA (human leukocyte antigen) Cw*06 allele demonstrates the strongest 
      association with susceptibility to early-onset psoriasis in most populations. 
      Recent data have indicated that late-onset psoriasis (LOP) demonstrates only a 
      weak association with Cw*0602, and suggest that this type of psoriasis may 
      represent a distinct subtype of the disease. The aim of this study was to compare 
      the frequency of human leukocyte antigen C (HLA-C) alleles in patients with LOP 
      and in healthy subjects within the same ethnic group in northern Poland. HLA-C 
      alleles of 89 patients with psoriasis with onset at the age of 40 y or later and 
      80 control subjects were determined by a polymerase chain reaction (PCR), 
      low-resolution method. The results showed that the Cw*05 allele was detected less 
      frequently in patients with LOP than in control subjects, but this failed to 
      retain significance after correction for multiple comparisons. There were no 
      differences in the frequency of other HLA-C alleles between the patients and the 
      control group. Our results confirm no association between HLA-C alleles and LOP 
      in the northern Polish population. The lack of this association supports the 
      hypothesis about different genetic backgrounds of early- and late-onset 
      psoriasis.
FAU - Szczerkowska-Dobosz, Aneta
AU  - Szczerkowska-Dobosz A
AD  - Department of Dermatology, Medical University of Gdansk, Debinki 7, 80-211 
      Gdansk, Poland. adobosz@amg.gda.pl
FAU - Niespodziana, Katarzyna
AU  - Niespodziana K
FAU - Rebala, Krzysztof
AU  - Rebala K
FAU - Garstecka, Joanna
AU  - Garstecka J
FAU - Lange, Magdalena
AU  - Lange M
FAU - Baranska-Rybak, Wioletta
AU  - Baranska-Rybak W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Genet
JT  - Journal of applied genetics
JID - 9514582
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Poland
MH  - *Polymorphism, Genetic
MH  - Psoriasis/*genetics
EDAT- 2007/08/02 09:00
MHDA- 2007/10/19 09:00
CRDT- 2007/08/02 09:00
PHST- 2007/08/02 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/08/02 09:00 [entrez]
AID - 404 [pii]
AID - 10.1007/BF03195223 [doi]
PST - ppublish
SO  - J Appl Genet. 2007;48(3):273-5. doi: 10.1007/BF03195223.