PMID- 17667803
OWN - NLM
STAT- MEDLINE
DCOM- 20070828
LR  - 20220331
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 84
IP  - 2
DP  - 2007 Jul 27
TI  - Effect of human leukocyte antigen compatibility on kidney graft survival: 
      comparative analysis of two decades.
PG  - 137-43
AB  - BACKGROUND: Based on an analysis of United Network for Organ Sharing data, it was 
      reported that the influence of human leukocyte antigen (HLA) matching in renal 
      transplantation has diminished in recent years, prompting the suggestion that 
      donor kidney allocation algorithms should be revised. METHODS: We compared the 
      impact of HLA matching on kidney graft survival during the decades 1985-1994 and 
      1995-2004 using the data of the Collaborative Transplant Study. Results for the 
      last 5 years (2000-2004) were analyzed separately in addition. Multivariate Cox 
      regression analysis was used to account for the influence of confounders. 
      RESULTS: Our results show that, while graft survival rates have improved overall 
      over time, the relative impact of HLA matching on the graft survival rate has 
      remained strong and highly significant. Both the need for posttransplant 
      rejection treatment and the graft survival rates showed statistically highly 
      significant associations with HLA matching regardless of the interval analyzed 
      (P<0.001). CONCLUSIONS: We conclude that HLA mismatches significantly influence 
      the outcome of kidney transplants and that kidney exchange programs for the 
      purpose of achieving better HLA matches continue to be meaningful.
FAU - Opelz, Gerhard
AU  - Opelz G
AD  - Department of Transplantation Immunology, University of Heidelberg, Heidelberg, 
      Germany. gerhard.opelz@med.uni-heidelberg.de
FAU - Dohler, Bernd
AU  - Dohler B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Follow-Up Studies
MH  - Graft Rejection/immunology
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Transplantation/*immunology
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Time Factors
EDAT- 2007/08/02 09:00
MHDA- 2007/08/29 09:00
CRDT- 2007/08/02 09:00
PHST- 2007/08/02 09:00 [pubmed]
PHST- 2007/08/29 09:00 [medline]
PHST- 2007/08/02 09:00 [entrez]
AID - 00007890-200707270-00002 [pii]
AID - 10.1097/01.tp.0000269725.74189.b9 [doi]
PST - ppublish
SO  - Transplantation. 2007 Jul 27;84(2):137-43. doi: 
      10.1097/01.tp.0000269725.74189.b9.