PMID- 17669079
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20070802
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30
IP  - 8
DP  - 2007 Aug
TI  - Predictors of a positive response to biventricular pacing in patients with severe 
      heart failure and ventricular conduction delay.
PG  - 970-5
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) is recommended in patients 
      with ejection fraction <35%, QRS width> 120 ms, and New York Heart Association 
      (NYHA) functional class III or IV despite optimal medical therapy. We aimed to 
      define demographic, clinical, and electrocardiographic predictors of positive 
      clinical response to CRT. METHODS AND RESULTS: Hundred consecutive patients 
      fulfilling the recommended criteria were implanted with a CRT device. 
      Demographic, clinical, two-dimensional echocardiographic and electrographic 
      parameters were measured at baseline and after 6 months of simultaneous 
      biventricular pacing. A positive response to CRT included an improvement of at 
      least one NYHA functional class associated with an absence of hospitalization for 
      worsening heart failure. At the end of follow-up, 12 patients were dead and 71% 
      of the patients were classified as responders. After 6 months of CRT, the 
      ejection fraction was significantly higher (P = 0.035) in responders versus 
      nonresponders. Multivariate analysis identified three independent predictors of 
      positive response to CRT: an idiopathic origin of the cardiomyopathy (P = 0.043), 
      a wider QRS before implantation (P = 0.017), and a narrowing of the QRS after 
      implantation (P = 0.037). CONCLUSION: An idiopathic origin of the cardiomyopathy, 
      a wider QRS before implantation, and a narrowing of the QRS width after 
      implantation were identified as independent predictors of clinical positive 
      response to CRT.
FAU - Yeim, Sunthareth
AU  - Yeim S
AD  - Hospital Haut Leveque, Service Pr Clementy, Pessac, France.
FAU - Bordachar, Pierre
AU  - Bordachar P
FAU - Reuter, Sylvain
AU  - Reuter S
FAU - Laborderie, Julien
AU  - Laborderie J
FAU - O'Neill, Mark D
AU  - O'Neill MD
FAU - Lafitte, Stephane
AU  - Lafitte S
FAU - Deplagne, Antoine
AU  - Deplagne A
FAU - Garrigue, Stephane
AU  - Garrigue S
FAU - Roudaut, Raymond
AU  - Roudaut R
FAU - Jais, Pierre
AU  - Jais P
FAU - Haissaguerre, Michel
AU  - Haissaguerre M
FAU - Dossantos, Pierre
AU  - Dossantos P
FAU - Clementy, Jacques
AU  - Clementy J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Electrocardiography
MH  - Female
MH  - Heart Conduction System/*physiopathology
MH  - Heart Failure/complications/*physiopathology/*therapy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Ventricular Dysfunction/complications/*physiopathology/*therapy
EDAT- 2007/08/03 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/08/03 09:00
PHST- 2007/08/03 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/08/03 09:00 [entrez]
AID - PACE794 [pii]
AID - 10.1111/j.1540-8159.2007.00794.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Aug;30(8):970-5. doi: 
      10.1111/j.1540-8159.2007.00794.x.