PMID- 1767076
OWN - NLM
STAT- MEDLINE
DCOM- 19920218
LR  - 20131121
IS  - 0889-857X (Print)
IS  - 0889-857X (Linking)
VI  - 17
IP  - 4
DP  - 1991 Nov
TI  - The immunogenetics of juvenile rheumatoid arthritis.
PG  - 825-42
AB  - Recent major advances in understanding the genetic structure of the human 
      leukocyte antigen (HLA) region and how HLA molecules contribute to immune 
      responses have been paralleled by more precise identification of specific HLA 
      genes conferring susceptibility to the various forms of juvenile rheumatoid 
      arthritis (JRA). This article presents current models for HLA-associated 
      autoimmune disease susceptibility and summarizes the HLA Class II alleles 
      currently known to be associated with JRA: primarily DR8, DR5, DR6, and DPw2.1 in 
      pauciarticular onset JRA; and DR4 in rheumatoid factor-positive polyarticular 
      onset JRA. Rheumatoid factor-negative polyarticular onset JRA and systemic onset 
      JRA are variously associated with several of these same genes. Gene interactions 
      and the clinical utility of HLA typing in this disease are also discussed.
FAU - Nepom, B
AU  - Nepom B
AD  - Immunology Program, Virginia Mason Research Center, Seattle, Washington.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Rheum Dis Clin North Am
JT  - Rheumatic diseases clinics of North America
JID - 8708093
RN  - 0 (HLA-D Antigens)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Antibody Formation/physiology
MH  - Arthritis, Juvenile/genetics/*immunology
MH  - Genetic Predisposition to Disease
MH  - HLA-D Antigens/analysis/physiology
MH  - Humans
MH  - Immunogenetics
MH  - Rheumatoid Factor/analysis
RF  - 59
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
PST - ppublish
SO  - Rheum Dis Clin North Am. 1991 Nov;17(4):825-42.