PMID- 17671381
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20151119
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 75
IP  - 2-3
DP  - 2007
TI  - Symptom resolution does not predict healing of erosive oesophagitis in Chinese.
PG  - 128-34
AB  - BACKGROUND: Previous studies suggested that Chinese have a milder spectrum of 
      gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors 
      (PPI) is sufficient for the control of symptoms as compared with the Western 
      population. AIMS: To determine if 8 weeks of esomeprazole 20 mg daily would be 
      adequate for both symptom resolution and oesophagitis healing in Chinese patients 
      and the predictive factors for the response. METHODS: 66 patients with 
      oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) 
      classification. 61 patients underwent 24-hour ambulatory pH study at baseline. 
      All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing 
      of oesophagitis was assessed at the end of the treatment period. RESULTS: 75.8% 
      of the patients had complete reflux symptom resolution but only 48% had complete 
      healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA 
      classification grading at baseline endoscopy (p < 0.0001) and total number acid 
      reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both 
      good predictors of oesophagitis healing but not for symptom resolution. 
      CONCLUSIONS: Our results suggested that 8 weeks of lower dose PPI is not 
      sufficient for oesophagitis healing. Symptom resolution with PPI does not predict 
      oesophagitis healing in Chinese.
CI  - 2007 S. Karger AG, Basel
FAU - Cheung, Ting Kin
AU  - Cheung TK
AD  - Department of Medicine, University of Hong Kong, Hong Kong, SAR, China.
FAU - Wong, Wai Man
AU  - Wong WM
FAU - Wong, Nina Y H
AU  - Wong NY
FAU - Chan, Chi Kuen
AU  - Chan CK
FAU - Fung, James
AU  - Fung J
FAU - Yuen, Man Fung
AU  - Yuen MF
FAU - Chan, Annie O O
AU  - Chan AO
FAU - Tong, Teresa S M
AU  - Tong TS
FAU - Wong, Benjamin C Y
AU  - Wong BC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070713
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Anti-Ulcer Agents)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Chi-Square Distribution
MH  - China
MH  - Esomeprazole/*therapeutic use
MH  - Esophagitis/*drug therapy/*ethnology
MH  - Esophagoscopy
MH  - Female
MH  - Gastric Acidity Determination
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Logistic Models
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2007/08/03 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/08/03 09:00
PHST- 2007/04/02 00:00 [received]
PHST- 2007/06/13 00:00 [accepted]
PHST- 2007/08/03 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/08/03 09:00 [entrez]
AID - 000106453 [pii]
AID - 10.1159/000106453 [doi]
PST - ppublish
SO  - Digestion. 2007;75(2-3):128-34. doi: 10.1159/000106453. Epub 2007 Jul 13.