PMID- 17672076
OWN - NLM
STAT- MEDLINE
DCOM- 20070820
LR  - 20131121
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 79
IP  - 5
DP  - 2007
TI  - [Factors affecting efficacy of proton pump inhibitors in NAID-induced gastric 
      ulcers].
PG  - 54-9
AB  - AIM: To determine factors which may influence efficacy of therapy with proton 
      pump inhibitors (PPI) in gastric ulcer (GU) induced by nonsteroid 
      anti-inflammatory drugs (NAID). MATERIAL AND METHODS: Two groups of GU patients 
      treated with PPI in 2001-2005 were identified: 41 cases when ulcer healing was 
      not achieved for 3 weeks and more (study group) and 218 cases treated for this 
      time successfully (controls). The groups did not differ significantly by gender 
      (females 84.6 and 78.6%) and age (59.2 +/- 16.8 and 58.7 +/- 12.4 years). 
      RESULTS: The patients of the study group had ulcers of 10 mm and more in size 
      much more frequently than the controls (OR 12.5, CI 5.8-26). Also, rheumatoid 
      arthritis (RA), ulcer history, intake of glucocorticosteroids, cytotoxic drugs, 
      ineffective preventive treatment with PPI (OR 5.3, CI 3.4-8.4; OR 3.1, CI 
      1.5-6.0; OR 3.1, CI 1.6-6.0; OR 3.4, CI 1.7-6.7; OR 2.7, CI 1.3-5.6, 
      respectively) were recorded in the study group more often. Helicobacter pylori 
      was absent in 75.6% patients of the study group but these findings can not be 
      compared with those in the controls as the majority of them had not been examined 
      for gastric H. pylori. CONCLUSION: Large ulcer, RA, ulcer history, treatment with 
      GCS, cytotoxic drugs, PPI and, probably, the absence of H. pylori decrease 
      efficacy of PPI in gastric ulcer induced by NAID.
FAU - Karateev, A E
AU  - Karateev AE
FAU - Diukov, I V
AU  - Diukov IV
LA  - rus
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Anti-Ulcer Agents/administration & dosage/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/administration & dosage/*therapeutic use
MH  - *Proton Pump Inhibitors
MH  - Stomach Ulcer/chemically induced/*drug therapy/metabolism/pathology
MH  - Treatment Outcome
EDAT- 2007/08/04 09:00
MHDA- 2007/08/21 09:00
CRDT- 2007/08/04 09:00
PHST- 2007/08/04 09:00 [pubmed]
PHST- 2007/08/21 09:00 [medline]
PHST- 2007/08/04 09:00 [entrez]
PST - ppublish
SO  - Ter Arkh. 2007;79(5):54-9.