PMID- 17672303
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20201209
IS  - 0001-6209 (Print)
IS  - 0001-6209 (Linking)
VI  - 47
IP  - 3
DP  - 2007 Jun
TI  - [Effect of Terric acid on the growth, cellular morphology and macromolecular 
      synthesis of C. albicans].
PG  - 447-51
AB  - Terric acid,an antifungal metabolites produced by a marine mold Aspergillus 
      flavis No. 179, was isolated and purified. The effects of terric acid at 
      different concertrations on the growth and cellular morphology of C. albicans 
      AS2, 538 were studied by the method of liquid dilution. The substance inhibits 
      the growth of C. albicans AS2,538 obviously at low concentration and has 
      fungicidal action at high concentration. The minimum inhibiting concentrations 
      (MIC) and minimum lethal concentrations (MLC) on C. albicans AS2,538 were 6.25 
      microg/mL and 50 microg/mL, respectively. At Sub-MIC (3.13 microg/mL), terric 
      acid inhibited the formation of pseudo-hyphal of C. albicans AS2, 538 and caused 
      cell morphological change. After addition of terric acid to the medium to final 
      concentration of 50 microg/mL, cell morphology of C. albicans AS2, 538 was 
      irregular and some cells turned bigger and disrupted. The effects of terric acid 
      on the synthesis of macromolecules, DNA, RNA or proteins of C. albicans AS2, 538 
      were estimated by measurement of incorporation of radioactive precursors, 
      14C-Thymidine, 3H-Uridine or 14 C-Valine, respectively. When C. albicans AS2, 538 
      was incubated for 4h in 5 g/mL terric acid medium, the incorporation of 
      radioactive isoleucine and uridine decreased 47.8%, 70.7%, respectively, Compared 
      with controls incubated in commonly medium. However, the incorporation of 
      [3H]thymidine did not have significant change. This results indicated that terric 
      acid inhibits the synthesis of protein and RNA but have no effect on DNA 
      synthesis in a C. albicans AS2,538.
FAU - Li, Shu-bin
AU  - Li SB
AD  - School of Life Science, South China Normal University, Guangzhou 510631, China. 
      zhourc@scnu.edu.cn
FAU - Wang, Jun
AU  - Wang J
FAU - Zhong, Ying-chang
AU  - Zhong YC
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Wei Sheng Wu Xue Bao
JT  - Wei sheng wu xue bao = Acta microbiologica Sinica
JID - 21610860R
RN  - 0 (Antifungal Agents)
RN  - 0 (Benzoquinones)
RN  - 0 (DNA, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Heterocyclic Compounds, 2-Ring)
RN  - 0 (RNA, Fungal)
RN  - 0 (terric acid)
SB  - IM
MH  - Antifungal Agents/metabolism/*pharmacology
MH  - Aspergillus/chemistry/metabolism
MH  - Benzoquinones/metabolism/*pharmacology
MH  - Candida albicans/cytology/*drug effects/*growth & development/metabolism
MH  - DNA Replication/drug effects
MH  - DNA, Fungal/genetics/*metabolism
MH  - Fungal Proteins/genetics/*metabolism
MH  - Heterocyclic Compounds, 2-Ring/metabolism/*pharmacology
MH  - Protein Biosynthesis/drug effects
MH  - RNA, Fungal/genetics/*metabolism
EDAT- 2007/08/04 09:00
MHDA- 2009/05/15 09:00
CRDT- 2007/08/04 09:00
PHST- 2007/08/04 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
PHST- 2007/08/04 09:00 [entrez]
PST - ppublish
SO  - Wei Sheng Wu Xue Bao. 2007 Jun;47(3):447-51.