PMID- 17673043
OWN - NLM
STAT- MEDLINE
DCOM- 20081010
LR  - 20070803
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 42
IP  - 5
DP  - 2007 May
TI  - [Pregnancy outcome in women with rheumatic heart disease].
PG  - 315-9
AB  - OBJECTIVE: To evaluate the pregnancy outcome of women with rheumatic heart 
      disease. METHODS: Clinical data of 65 cases of pregnant women with rheumatic 
      heart disease from Jan 1993 to July 2006 were analyzed. They were divided into 
      four groups according to the degree of mitral stenosis: normal group (> 4.0 
      cm(2)), slight group (2.5 - 4.0 cm(2)), moderate group (1.5 - 2.5 cm(2)) and 
      severe group (< 1.5 cm(2)); four groups according to the degree of pulmonary 
      hypertension: normal group, slight group (pulmonary hypertension ranging from 31 
      to 49 mm Hg, 1 mm Hg = 0.133 kPa) moderate group (from 50 to 79 mm Hg) and severe 
      group (equal to and more than 80 mm Hg); two groups according to heart operation: 
      non-operated group and operated group; and four groups according to the degree of 
      New York heart association (NYHA) class. The perinatal mortality and morbidity of 
      mothers and fetus were analysed. RESULTS: (1) The rate of NYHA class IV was 80% 
      (12/15 cases) in moderate-severe group of mitral stenosis and the rate of NYHA 
      class I and II was 80% (16/20 cases) in normal group, with a significant 
      difference between them (P < 0.05). (2) The rate of NYHA class I and II was 73% 
      (24/33 cases) in group of normal pulmonary pressure and the rate of NYHA class IV 
      was 6/7 in severe group of pulmonary hypertension (P < 0.05). (3) The rate of 
      NYHA class I and II was 71% (10/14), and NYHA class III or IV was 14% (2/14) in 
      heart operated women (P < 0.05). (4) The delivery week was 34.6 and the birth 
      weight was 2176 g averagely in NYHA class IV group and had significant 
      differences from NYHA class I group (P < 0.05). There were 9 cases of abortion 
      medically (18.9%, 9/65), 18 of preterm labor medically (28%, 18/65), 4 of fetal 
      growth restriction (FGR) (6%, 4/65) and 3 of perinatal mortality (5%, 3/65), 
      which all happened in groups of NYHA class III and IV. (5) The rate of NYHA class 
      III and IV was 6/7 in atrial fibrillation women. CONCLUSION: Pregnant women with 
      rheumatic heart disease of moderate-severe mitral stenosis, severe pulmonary 
      hypertension and atrial fibrillation are at high risk of heart failure. The fetal 
      outcome is not good in cases of NYHA class III and IV.
FAU - Lin, Jian-Hua
AU  - Lin JH
AD  - Department of Obstetrics and Gynecology, Affiliated Renji Hospital, School of 
      Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
FAU - Ling, Wan-Wen
AU  - Ling WW
FAU - Liang, A-Juan
AU  - Liang AJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/complications/pathology/physiopathology
MH  - Infant, Newborn
MH  - Mitral Valve Stenosis/complications/pathology/physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/pathology/*physiopathology
MH  - *Pregnancy Outcome
MH  - Pregnancy, High-Risk
MH  - Retrospective Studies
MH  - Rheumatic Heart Disease/complications/pathology/*physiopathology
MH  - Severity of Illness Index
EDAT- 2007/08/04 09:00
MHDA- 2008/10/11 09:00
CRDT- 2007/08/04 09:00
PHST- 2007/08/04 09:00 [pubmed]
PHST- 2008/10/11 09:00 [medline]
PHST- 2007/08/04 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2007 May;42(5):315-9.