PMID- 17674765
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20070806
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 21
IP  - 11
DP  - 2007 Jun
TI  - [Expression and significance of tyrosine kinase receptors B in nasopharyngeal 
      carcinoma patients].
PG  - 497-500
AB  - OBJECTIVE: This study was to explore the expression and clinicopathologic 
      features of Tyrosine kinase receptors B (TrkB) and its ligand brain-derived 
      neurotrophic factor (BDNF) in nasopharyngeal carcinoma (NPC). METHOD: 
      Immunohistochemistry was adopted to detect the expression level of TrkB and BDNF 
      in NPC patients. RESULT: Both TrkB and BDNF were expressed in NPC as well as in 
      chronic inflammation. The active expression rate of TrkB in NPC was 82.5% (47/57) 
      and BDNF was 52.6% (30/57), both of which were higher than those in chronic 
      inflammation (P < 0.05). The degree of TrkB expression was more marked in T3 + 
      T4, III + IV stage NPC than that in T1 +T2, I + II stage NPC (P < 0.05). TrkB 
      abnormal expression rate of nasopharyngeal carcinoma with lymph node metastasis 
      was higher than that of NPC without lymph node metastasis (P < 0.05). No 
      statistical significance for degrees of TrkB expression in pathologic type grades 
      was found (P > 0.05). There were no statistical significance for degrees of BDNF 
      expression in T stage, clinical stage and lymph node metastasis in NPC (P > 
      0.05). The expression of TrkB was unrelated to the expression of BDNF (r = 0.049, 
      P > 0.05). CONCLUSION: The high expression rate of TrkB and BDNF maybe plays an 
      important role in development of NPC. It is suggested that TrkB and its ligand 
      BDNF may act as an important index for forecasting the development and metastasis 
      of NPC.
FAU - Zhao, Weimin
AU  - Zhao W
AD  - Department of Otolaryngology, Guangxi Municipal Corps Hospital, Chinese People's 
      Armed Police Forces, Nanning 530003, China.
FAU - Wen, Wensheng
AU  - Wen W
FAU - Zhang, Zhe
AU  - Zhang Z
FAU - Liao, Zhiling
AU  - Liao Z
FAU - Zhang, Shuxiang
AU  - Zhang S
FAU - Huang, Guangwu
AU  - Huang G
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*metabolism/*pathology
MH  - Neoplasm Staging
MH  - Receptor, trkB/*metabolism
MH  - Young Adult
EDAT- 2007/08/07 09:00
MHDA- 2011/06/03 06:00
CRDT- 2007/08/07 09:00
PHST- 2007/08/07 09:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PHST- 2007/08/07 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Jun;21(11):497-500.