PMID- 17675062
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20221207
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 13
IP  - 6
DP  - 2007 Aug
TI  - Heart failure mortality in Southeast Asian patients with left ventricular 
      systolic dysfunction.
PG  - 476-81
AB  - BACKGROUND: Prognostic indicators and mortality in multiethnic Southeast Asian 
      patients with heart failure (HF) may be different. METHODS AND RESULTS: The study 
      population comprised 225 inpatients with HF with a left ventricular ejection 
      fraction of 40% or less who were discharged alive. Five years later, survival and 
      causes of death were determined. Proportionally, more Malay and Indian patients 
      were admitted compared with Chinese patients (P < .001). There were 55.6% in New 
      York Heart Association (NYHA) class III or IV. Ischemic heart disease was the 
      most common cause (85.8%). At 5 years, 152 patients (67.5%) had died. 
      Angiotensin-converting enzyme inhibitors were prescribed to 79.1% of patients on 
      discharge. Cardiovascular causes accounted for 69.7% of deaths. Predictors of 
      mortality include female gender (P = .046), age 70 years or more (P = .017), 
      renal impairment (P = .008), NYHA class III or IV (P = .03), and non-use of 
      angiotensin-converting enzyme inhibitors (P = .005). On multivariate analysis, 
      increasing age (P = .001) and renal impairment (P = .019) were independent 
      predictors of all-cause mortality. Cardiovascular death was more likely with NYHA 
      class III or IV (P = .004) and renal impairment (P = .012). CONCLUSION: Mortality 
      is unusually high in this group of patients despite treatment. Greater use of 
      evidence-based therapies in HF-management programs may arrest this trend.
FAU - Seow, Swee-Chong
AU  - Seow SC
AD  - Heart Institute, National University Hospital, Singapore.
FAU - Chai, Ping
AU  - Chai P
FAU - Lee, Yian-Ping
AU  - Lee YP
FAU - Chan, Yiong-Huak
AU  - Chan YH
FAU - Kwok, Bernard W K
AU  - Kwok BW
FAU - Yeo, Tiong-Cheng
AU  - Yeo TC
FAU - Chia, Boon-Lock
AU  - Chia BL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - *Asian People
MH  - Cause of Death
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/ethnology/*mortality
MH  - Humans
MH  - India/ethnology
MH  - Malaysia/ethnology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Singapore/epidemiology
MH  - Survival Rate/trends
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/ethnology/*mortality
EDAT- 2007/08/07 09:00
MHDA- 2007/09/26 09:00
CRDT- 2007/08/07 09:00
PHST- 2006/09/13 00:00 [received]
PHST- 2007/03/13 00:00 [revised]
PHST- 2007/03/19 00:00 [accepted]
PHST- 2007/08/07 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/08/07 09:00 [entrez]
AID - S1071-9164(07)00101-7 [pii]
AID - 10.1016/j.cardfail.2007.03.010 [doi]
PST - ppublish
SO  - J Card Fail. 2007 Aug;13(6):476-81. doi: 10.1016/j.cardfail.2007.03.010.