PMID- 17675412
OWN - NLM
STAT- MEDLINE
DCOM- 20071213
LR  - 20131121
IS  - 0958-0670 (Print)
IS  - 0958-0670 (Linking)
VI  - 92
IP  - 6
DP  - 2007 Nov
TI  - Effect of angiotensin-converting enzyme inhibition on skeletal muscle oxidative 
      function and exercise capacity in streptozotocin-induced diabetic rats.
PG  - 1047-56
AB  - Since exercise capacity is related to the mitochondrial respiration rate in 
      skeletal muscle and both parameters are potentially modulated by the onset of 
      diabetes and by inhibition of the angiotensin-converting enzyme (ACE), we 
      investigated whether skeletal muscle oxidative functions and exercise capacities 
      are impaired in chronic streptozotocin-induced diabetic (STZ) rats and whether 
      ACE inhibition could reverse such abnormalities. The ACE inhibitor perindopril (2 
      mg kg(-1) day(-1)) was given for a period of 5 weeks to 7-month-old STZ rats 
      (DIA-PE, n = 8) whose haemodynamic function, skeletal muscle mitochondrial 
      function and exercise capacity were compared with those of untreated diabetic 
      (DIA, n = 8) and control rats (CONT, n = 8). Increased arterial blood pressure 
      (157 +/- 12 versus 130 +/- 6 mmHg, P < 0.05) and reduced exercise capacity (29 
      +/- 2 versus 91 +/- 2 min, respectively, P < 0.01) were observed in DIA compared 
      with CONT. The oxidative capacity of the gastrocnemius muscle was significantly 
      reduced in DIA compared with CONT rats (5.4 +/- 0.5 versus 10.6 +/- 0.7 micromol 
      O(2) min(-1)(g dry weight)(-1), respectively, P < 0.001). Moreover, the coupling 
      between oxidation and phosphorylation was significantly impaired in DIA (-52%, P 
      < 0.001). Angiotensin-converting enzyme inhibition (ACEi) normalized blood 
      pressure without improving mitochondrial function (4.3 +/- 0.8 micromol O(2) 
      min(-1) (g dry weight)(-1) in DIA-PE rats) but reduced exercise capacity to even 
      lower levels (10 +/- 1 min, P < 0.01). Exercise capacity correlated positively 
      with blood pressure in DIA-PE (r = 0.79, P < 0.05). In experimental type 1 
      diabetic rats, both skeletal muscle mitochondrial respiration and exercise 
      capacity are impaired. The ACEi failed to restore the muscular function and 
      worsened exercise capacity. Further studies will be useful to determine whether 
      an inadequate muscular blood flow secondary to the reduction in mean systemic 
      blood pressure can explain these results.
FAU - Rouyer, Olivier
AU  - Rouyer O
AD  - Physiology Institute and CHRU-Strasbourg, 1 PL de l'Hopital, Strasbourg 67091, 
      France.
FAU - Zoll, Joffrey
AU  - Zoll J
FAU - Daussin, Frederic
AU  - Daussin F
FAU - Damge, Christiane
AU  - Damge C
FAU - Helms, Pauline
AU  - Helms P
FAU - Talha, Sami
AU  - Talha S
FAU - Rasseneur, Laurence
AU  - Rasseneur L
FAU - Piquard, Francois
AU  - Piquard F
FAU - Geny, Bernard
AU  - Geny B
LA  - eng
PT  - Journal Article
DEP - 20070803
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 5W494URQ81 (Streptozocin)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/*pharmacology
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/drug effects/physiology
MH  - Cell Respiration/drug effects/physiology
MH  - Diabetes Mellitus, Experimental/*physiopathology
MH  - Insulin/blood
MH  - Male
MH  - Mitochondria, Muscle/drug effects/*physiology
MH  - Muscle, Skeletal/blood supply/drug effects/*physiopathology
MH  - Perindopril/*pharmacology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Regional Blood Flow/drug effects/physiology
MH  - Streptozocin
EDAT- 2007/08/07 09:00
MHDA- 2007/12/14 09:00
CRDT- 2007/08/07 09:00
PHST- 2007/08/07 09:00 [pubmed]
PHST- 2007/12/14 09:00 [medline]
PHST- 2007/08/07 09:00 [entrez]
AID - expphysiol.2007.038851 [pii]
AID - 10.1113/expphysiol.2007.038851 [doi]
PST - ppublish
SO  - Exp Physiol. 2007 Nov;92(6):1047-56. doi: 10.1113/expphysiol.2007.038851. Epub 
      2007 Aug 3.