PMID- 17678899
OWN - NLM
STAT- MEDLINE
DCOM- 20071019
LR  - 20211203
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 581
IP  - 21
DP  - 2007 Aug 21
TI  - Identification of S6K2 as a centrosome-located kinase.
PG  - 4058-64
AB  - Ribosomal S6 kinase 2 (S6K2) acts downstream of the mammalian target of rapamycin 
      (mTOR). Here, we show that some S6K2 localize at the centrosome throughout the 
      cell cycle. S6K2 is found in the pericentriolar area of the centrosome. S6K2 
      centrosomal localization is unaffected by serum withdrawal or treatment with 
      rapamycin, wortmannin, U0126, or phorbol-12-myristate-13-acetate (PMA). Unlike 
      S6K2, S6 kinase 1 (S6K1) does not localize at the centrosome, suggesting the two 
      kinases may also have nonoverlapping functions. Our data suggest that centrosomal 
      S6K2 may have a role in the phosphoinositide-3-kinase (PI3K)/Akt/mTOR signaling 
      pathway that has also been detected in the centrosome.
FAU - Rossi, Rossella
AU  - Rossi R
AD  - Istituto di Genetica Molecolare (IGM) - CNR, 27100 Pavia, Italy.
FAU - Pester, John M
AU  - Pester JM
FAU - McDowell, Mitch
AU  - McDowell M
FAU - Soza, Samuela
AU  - Soza S
FAU - Montecucco, Alessandra
AU  - Montecucco A
FAU - Lee-Fruman, Kay K
AU  - Lee-Fruman KK
LA  - eng
GR  - S06 GM063119/GM/NIGMS NIH HHS/United States
GR  - S06 GM063119-020004/GM/NIGMS NIH HHS/United States
GR  - 2 S06 GM063119-05/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070730
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Enzyme Inhibitors)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Cell Cycle/drug effects/*physiology
MH  - Centrosome/*enzymology
MH  - Enzyme Inhibitors/pharmacology
MH  - HeLa Cells
MH  - Humans
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Protein Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Ribosomal Protein S6 Kinases/antagonists & inhibitors/*metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - TOR Serine-Threonine Kinases
PMC - PMC2397023
MID - NIHMS28970
EDAT- 2007/08/07 09:00
MHDA- 2007/10/20 09:00
PMCR- 2008/08/21
CRDT- 2007/08/07 09:00
PHST- 2007/04/11 00:00 [received]
PHST- 2007/06/23 00:00 [revised]
PHST- 2007/07/02 00:00 [accepted]
PHST- 2007/08/07 09:00 [pubmed]
PHST- 2007/10/20 09:00 [medline]
PHST- 2007/08/07 09:00 [entrez]
PHST- 2008/08/21 00:00 [pmc-release]
AID - S0014-5793(07)00821-6 [pii]
AID - 10.1016/j.febslet.2007.07.047 [doi]
PST - ppublish
SO  - FEBS Lett. 2007 Aug 21;581(21):4058-64. doi: 10.1016/j.febslet.2007.07.047. Epub 
      2007 Jul 30.