PMID- 17679788
OWN - NLM
STAT- MEDLINE
DCOM- 20070824
LR  - 20191110
IS  - 1559-4564 (Print)
IS  - 1559-4564 (Linking)
VI  - 1
IP  - 5
DP  - 2006 Fall
TI  - Weight, the metabolic syndrome, and coronary heart disease in type 2 diabetes: 
      associations among a national French sample of adults with diabetes-the ENTRED 
      study.
PG  - 318-25
AB  - The authors examined whether obesity alone or as part of the metabolic syndrome 
      (MS) increases coronary heart disease (CHD) risk in type 2 diabetes mellitus 
      (T2DM) among 2970 adults aged 30-79 years in a French national sample. MS was 
      defined as T2DM plus self-report of 2 or more of the following: body mass index 
      >30 kg/m(2), diagnosed hypertension, or diagnosed dyslipidemia. A subsample with 
      physician-reported data (n =841) was further classified with measured 
      hypertension and dyslipidemia. Weight distribution included normal (21%), 
      overweight (42%), and obese (37%). A 20% increased odds of CHD was estimated for 
      every 5-kg/m(2) body mass index increase (P=.0001). MS was associated with a more 
      than 2-fold higher risk of CHD compared with T2DM without MS (P<.0001, 
      multivariate-adjusted [both samples]). With MS stratified by high-density 
      lipoprotein cholesterol (<1.5 vs > or =1.5 mmol/L), compared with no MS, the odds 
      ratio for CHD was 2.8 (normal-level high-density lipoprotein MS; 95% confidence 
      interval, 1.8-4.5) and 1.5 (high-level high-density lipoprotein MS; 95% 
      confidence interval, 0.8-2.9). The authors suggest that obesity alone--and 
      particularly when the MS is present--increases CHD risk in patients with T2DM. 
      High levels of high-density lipoprotein may modify this relationship.
FAU - Hillier, Teresa A
AU  - Hillier TA
AD  - Institut National de la Sante et de la Recherche Medicale U258-IFR69, University 
      Paris XI, Villejuif, France. teresa.hillier@kpchr.org
FAU - Fosse, Sandrine
AU  - Fosse S
FAU - Balkau, Beverley
AU  - Balkau B
FAU - Simon, Dominique
AU  - Simon D
FAU - Eschwege, Eveline
AU  - Eschwege E
FAU - Fagot-Campagna, Anne
AU  - Fagot-Campagna A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiometab Syndr
JT  - Journal of the cardiometabolic syndrome
JID - 101284690
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - *Body Weight
MH  - Cholesterol, HDL/blood
MH  - Coronary Disease/blood/epidemiology/*etiology/physiopathology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*epidemiology/physiopathology
MH  - Diabetic Angiopathies/blood/epidemiology/*etiology/physiopathology
MH  - Dyslipidemias/complications/epidemiology
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Hypertension/complications/epidemiology
MH  - Male
MH  - Metabolic Syndrome/blood/complications/*epidemiology/physiopathology
MH  - Middle Aged
MH  - Obesity/blood/complications/*epidemiology/physiopathology
MH  - Odds Ratio
MH  - Population Surveillance
MH  - Risk Assessment
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2007/08/08 09:00
MHDA- 2007/08/25 09:00
CRDT- 2007/08/08 09:00
PHST- 2007/08/08 09:00 [pubmed]
PHST- 2007/08/25 09:00 [medline]
PHST- 2007/08/08 09:00 [entrez]
AID - 10.1111/j.1559-4564.2006.05737.x [doi]
PST - ppublish
SO  - J Cardiometab Syndr. 2006 Fall;1(5):318-25. doi: 
      10.1111/j.1559-4564.2006.05737.x.