PMID- 17680607
OWN - NLM
STAT- MEDLINE
DCOM- 20071217
LR  - 20191210
IS  - 0012-1630 (Print)
IS  - 0012-1630 (Linking)
VI  - 49
IP  - 6
DP  - 2007 Sep
TI  - Binge-like ethanol exposure during the early postnatal period impairs eyeblink 
      conditioning at short and long CS-US intervals in rats.
PG  - 589-605
AB  - Binge-like ethanol exposure on postnatal days (PD) 4-9 in rodents causes 
      cerebellar cell loss and impaired acquisition of conditioned responses (CRs) 
      during "short-delay" eyeblink classical conditioning (ECC), using optimal 
      (280-350 ms) interstimulus intervals (ISIs). We extended those earlier findings 
      by comparing acquisition of delay ECC under two different ISIs. From PD 4 to 9, 
      rats were intubated with either 5.25 g/kg of ethanol (2/day), sham intubated, or 
      were not intubated. They were then trained either as periadolescents (about PD 
      35) or as adults (>PD 90) with either the optimal short-delay (280-ms) ISI, a 
      long-delay (880-ms) ISI, or explicitly unpaired CS and US presentations. Neonatal 
      binge ethanol treatment significantly impaired acquisition of conditioning at 
      both ages regardless of ISI, and deficits in the acquisition and expression of 
      CRs were comparable across ISIs. These deficits are consistent with the 
      previously documented ethanol-induced damage to the cerebellar-brainstem circuit 
      essential for Pavlovian ECC.
FAU - Tran, Tuan D
AU  - Tran TD
AD  - Department of Psychology, East Carolina University, Greenville, NC 27858, USA. 
      trant@ecu.edu
FAU - Stanton, Mark E
AU  - Stanton ME
FAU - Goodlett, Charles R
AU  - Goodlett CR
LA  - eng
GR  - AA014288/AA/NIAAA NIH HHS/United States
GR  - AA09838/AA/NIAAA NIH HHS/United States
GR  - AA11945/AA/NIAAA NIH HHS/United States
GR  - T32AA07462/AA/NIAAA NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Age Factors
MH  - *Alcohol Drinking
MH  - Animals
MH  - Animals, Newborn
MH  - Blinking/*drug effects
MH  - Central Nervous System Depressants/*administration & dosage/*pharmacology
MH  - Conditioning, Psychological/*drug effects
MH  - Electromyography
MH  - Ethanol/*administration & dosage/*pharmacology
MH  - *Periodicity
MH  - Random Allocation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Time Factors
EDAT- 2007/08/08 09:00
MHDA- 2007/12/18 09:00
CRDT- 2007/08/08 09:00
PHST- 2007/08/08 09:00 [pubmed]
PHST- 2007/12/18 09:00 [medline]
PHST- 2007/08/08 09:00 [entrez]
AID - 10.1002/dev.20226 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2007 Sep;49(6):589-605. doi: 10.1002/dev.20226.