PMID- 17680908
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20171116
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 18
IP  - 6
DP  - 2007 Sep
TI  - Sensitization to serum albumins in children allergic to cow's milk and epithelia.
PG  - 503-7
AB  - Patients with persistent milk allergy and specific immunoglobulin E (IgE) to 
      bovine serum albumin (BSA) have a greater risk of rhinoconjunctivitis and asthma 
      because of animal dander. To prove the cross-reactivity between serum albumin 
      (SA) of different mammals in milk, meat, and epithelia and determine if heat 
      treatment of meats decrease the allergenicity of albumins. The study was 
      performed using SDS-PAGE and IgE-immunoblotting using sera from eight patients 
      sensitized to milk, BSA, and animal danders. Sera from non-allergic and only 
      animal dander allergic subjects served as a control. With one exception, all 
      patients' sera recognized SA in different meats (beef, lamb, deer, and pork), 
      epithelia (dog, cat, and cow), and cow's milk. Some patients even were only 
      sensitized to SA in meat and epithelia. Danders' allergic only recognized other 
      proteins in epithelia but not SA. No patients reacted to SA from heated meat 
      extracts. Serum albumin is an important allergen involved in milk, meat, and 
      epithelia allergy. The first contact with SA was through cow's milk and patients 
      developed sensitization to epithelia SA even without direct contact with animals. 
      Patients with both BSA and cow's milk allergy must avoid raw meats and furry 
      pets.
FAU - Vicente-Serrano, J
AU  - Vicente-Serrano J
AD  - Department of Allergology, Hospital General Yague, Burgos, Spain. jvicente@hgy.es
FAU - Caballero, M L
AU  - Caballero ML
FAU - Rodriguez-Perez, R
AU  - Rodriguez-Perez R
FAU - Carretero, P
AU  - Carretero P
FAU - Perez, R
AU  - Perez R
FAU - Blanco, J G
AU  - Blanco JG
FAU - Juste, S
AU  - Juste S
FAU - Moneo, I
AU  - Moneo I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Serum Albumin)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Asthma/*immunology
MH  - Cats
MH  - Cattle
MH  - Child
MH  - Conjunctivitis, Allergic/*immunology
MH  - Cross Reactions
MH  - Deer
MH  - Dogs
MH  - Epithelial Cells/*immunology
MH  - Female
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Meat/*adverse effects
MH  - Milk Hypersensitivity/*immunology
MH  - Rhinitis/*immunology
MH  - Serum Albumin/adverse effects/*immunology
MH  - Serum Albumin, Bovine/immunology
MH  - Sheep
MH  - Skin Tests
MH  - Swine
EDAT- 2007/08/08 09:00
MHDA- 2007/10/05 09:00
CRDT- 2007/08/08 09:00
PHST- 2007/08/08 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2007/08/08 09:00 [entrez]
AID - PAI548 [pii]
AID - 10.1111/j.1399-3038.2007.00548.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2007 Sep;18(6):503-7. doi: 
      10.1111/j.1399-3038.2007.00548.x.