PMID- 17680923 OWN - NLM STAT- MEDLINE DCOM- 20071107 LR - 20070807 IS - 1398-5647 (Print) IS - 1398-5647 (Linking) VI - 9 IP - 5 DP - 2007 Aug TI - Brain-derived neurotrophic factor (BDNF) gene not associated with antidepressant-induced mania. PG - 521-5 AB - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of bipolar disorder (BPD). Moreover, increasing BDNF production might be one of the mechanisms involved in the alleviation of depression and aggravation of mania in antidepressant treatment. OBJECTIVES: Thus, we hypothesized that a genetic variant within the BDNF gene might influence susceptibility to antidepressant-induced mania, as has been suggested previously. METHODS: We performed a case-control study to test for allelic frequency and genotype distribution differences across six BDNF polymorphisms between 27 patients with antidepressant-induced mania (IM+) and 29 patients without antidepressant-induced mania (IM-). RESULTS: We did not observe any significant difference in either allelic or genotype frequencies between the two groups. CONCLUSIONS: Our results did not support the BDNF link to mania hypothesis proposed previously. However, a larger sample would allow for greater power to determine smaller effects of the BDNF gene in antidepressant-induced mania. FAU - Zai, Gwyneth AU - Zai G AD - Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, Ontario, Canada. FAU - Mundo, Emanuela AU - Mundo E FAU - Strauss, John AU - Strauss J FAU - Wong, Gregory W H AU - Wong GW FAU - Kennedy, James L AU - Kennedy JL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Bipolar Disord JT - Bipolar disorders JID - 100883596 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Alleles MH - Antidepressive Agents/*adverse effects MH - *Bipolar Disorder/chemically induced/epidemiology/genetics MH - Brain-Derived Neurotrophic Factor/*genetics/physiology MH - Case-Control Studies MH - Depressive Disorder/*drug therapy/*epidemiology MH - Gene Frequency MH - Genotype MH - Humans MH - Polymorphism, Genetic/genetics EDAT- 2007/08/08 09:00 MHDA- 2007/11/08 09:00 CRDT- 2007/08/08 09:00 PHST- 2007/08/08 09:00 [pubmed] PHST- 2007/11/08 09:00 [medline] PHST- 2007/08/08 09:00 [entrez] AID - BDI416 [pii] AID - 10.1111/j.1399-5618.2007.00416.x [doi] PST - ppublish SO - Bipolar Disord. 2007 Aug;9(5):521-5. doi: 10.1111/j.1399-5618.2007.00416.x.