PMID- 17684064
OWN - NLM
STAT- MEDLINE
DCOM- 20080425
LR  - 20151119
IS  - 1099-5129 (Print)
IS  - 1099-5129 (Linking)
VI  - 9
IP  - 10
DP  - 2007 Oct
TI  - The BRIGHT study: bifocal right ventricular resynchronization therapy: a 
      randomized study.
PG  - 857-61
AB  - AIMS: The BRIGHT study evaluated bifocal right ventricular (RV) (apex and outflow 
      tract) pacing in a single, blind, randomized crossover study in patients eligible 
      for cardiac resynchronization therapy (CRT). Forty-two patients were enrolled 
      with the following characteristics: chronic drug refractory heart failure New 
      York Heart Association (NYHA) class III-IV; ejection fraction (EF)<35%; QRS width 
      >or= 120 ms; and a left bundle branch block. The aim of the study was to assess 
      an improvement in left ventricular (LV) EF, 6 min walk test, Minnesota 
      quality-of-life score, and NYHA classification. Methods and result Patients were 
      randomized to receive either bifocal pacing or the control mode, each for a 
      period of 3 months. Parameters were measured prior to randomization and after 3 
      months of control or bifocal pacing. Eight patients failed to make the 7 month 
      follow-up, three patients died (one prior to randomization at the first month), 
      five patients dropped out, and three patients refused further participation. One 
      patient had a persistent lead problem, which was subsequently replaced with an LV 
      lead, and one patient suffered with persistent atrial fibrillation. Compared with 
      baseline, bifocal pacing improved EF from 26 +/- 12% to 36 +/- 11% (P < 0.0008), 
      NYHA classification decreased from 2.8 +/- 0.4 to 2.3 +/- 0.7 (P < 0.007). 
      Furthermore, the 6 min walk test improved from 372 +/- 129 m to 453 +/- 122 m (P 
      < 0.05), and the Minnesota Living with Heart Failure scores decreased from 33 +/- 
      20 to 24 +/- 21 (P < 0.006). In the control group, no significant changes in any 
      parameters were observed. Eight patients did not tolerate reprogramming from DDD 
      BRIGHT to control pacing, with symptoms disappearing in all patients after 
      reprogramming to bifocal pacing. CONCLUSION: Bifocal RV pacing in patients with a 
      classic indication for CRT shows improvement in all parameters.
FAU - Res, Jan C J
AU  - Res JC
AD  - Department of Cardiology, Ba 579, Erasmus Medical Centre Rotterdam, PO Box 2040, 
      3000 CA Rotterdam, The Netherlands. j.res@erasmusmc.nl
FAU - Bokern, Marcel J J A
AU  - Bokern MJ
FAU - de Cock, Carel C
AU  - de Cock CC
FAU - van Loenhout, Ton
AU  - van Loenhout T
FAU - Bronzwaer, Patrick N A
AU  - Bronzwaer PN
FAU - Spierenburg, Han A M
AU  - Spierenburg HA
CN  - BRIGHT Investigators
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20070807
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/etiology/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Heart Failure/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Quality of Life
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Right/etiology/physiopathology/therapy
EDAT- 2007/08/09 09:00
MHDA- 2008/04/26 09:00
CRDT- 2007/08/09 09:00
PHST- 2007/08/09 09:00 [pubmed]
PHST- 2008/04/26 09:00 [medline]
PHST- 2007/08/09 09:00 [entrez]
AID - eum147 [pii]
AID - 10.1093/europace/eum147 [doi]
PST - ppublish
SO  - Europace. 2007 Oct;9(10):857-61. doi: 10.1093/europace/eum147. Epub 2007 Aug 7.